Wang Zijian, Liang Xiao, Wang Guanyi, Wang Xinghuan, Chen Yun
Department of Biomedical Engineering, Hubei Province Key Laboratory of Allergy and Immune Related Disease, TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, 430071, China.
Department of Urology, Hubei Province Key Laboratory of Urinary System Diseases, Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Adv Mater. 2023 Aug 11:e2304738. doi: 10.1002/adma.202304738.
Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting has become one of the growing centers in the field of wound healing, with various types of bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted devices can be designed with specific biostructures and biofunctions that closely match the shape of wound sites and accelerate the regeneration of skin through various approaches. Herein, a comprehensive review of the bioprinting of smart wound dressings is presented, emphasizing the crucial effect of bioprinting in determining biostructures and biofunctions. The review begins with an overview of bioprinting techniques and bioprinted devices, followed with an in-depth discussion of polymer-based inks, modification strategies, additive ingredients, properties, and applications. The strategies for the modification of bioprinted devices are divided into seven categories, including chemical synthesis of novel inks, physical blending, coaxial bioprinting, multimaterial bioprinting, physical absorption, chemical immobilization, and hybridization with living cells, and examples are presented. Thereafter, the frontiers of bioprinting and wound healing, including 4D bioprinting, artificial intelligence-assisted bioprinting, and in situ bioprinting, are discussed from a perspective of interdisciplinary sciences. Finally, the current challenges and future prospects in this field are highlighted.
生物打印因其适用于制造生物医学设备而备受关注。特别是，生物打印已成为伤口愈合领域不断发展的核心领域之一，各种类型的生物打印设备正在被开发，包括3D支架、微针贴片和柔性电子产品。生物打印设备可以设计成具有特定生物结构和生物功能的形式，这些结构和功能与伤口部位的形状紧密匹配，并通过各种方法加速皮肤再生。在此，本文对智能伤口敷料的生物打印进行了全面综述，强调了生物打印在确定生物结构和生物功能方面的关键作用。综述首先概述了生物打印技术和生物打印设备，随后深入讨论了基于聚合物的墨水、改性策略、添加剂成分、特性和应用。生物打印设备的改性策略分为七类，包括新型墨水的化学合成、物理混合、同轴生物打印、多材料生物打印、物理吸附、化学固定以及与活细胞杂交，并给出了实例。此后，从跨学科科学的角度讨论了生物打印和伤口愈合的前沿领域，包括4D生物打印、人工智能辅助生物打印和原位生物打印。最后，强调了该领域当前的挑战和未来前景。
