Atarieh Masoomeh, Javadian Maryam, Basirat Zahra, Kashifard Mehdi, Yazdani Shahla, Adib-Rad Hajar, Abdollahzade-Delavar Maryam, Gholinia Hemmat
Infertility and Health Reproductive Research Center, Health Research Institute Babol University of Medical Sciences Babol Iran.
Clinical Research Development Unite of Rouhani Hospital Babol University of Medical Sciences Babol Iran.
Health Sci Rep. 2024 Aug 8;7(8):e2296. doi: 10.1002/hsr2.2296. eCollection 2024 Aug.
One of the causes of preterm labor and recurrent abortion is progesterone deficiency in the luteal phase. The aim of the study was a comparison of the effect of oral dydrogesterone and vaginal progesterone for luteal-phase support (LPS) in assisted reproductive technology cycles (ART).
This randomized clinical control trial study was conducted on 207 infertile women. Samples were randomly divided into two groups. The first group received a natural micronized vaginal progesterone (MVP) of 400 mg once daily and the second group received dydrogesterone (Duphestone) 20 mg twice daily. Then chemical pregnancy, abortion, and live births were compared in two groups.
The results of the study showed that the vaginal form of the drug could increase the chance of pregnancy (positive β-human chorionic gonadotropin) versus the oral form. According to the results of multiple logistic regression analysis after adjusting for other variables, the live birth rate in the vaginal group was more than five times that of the oral group (odds ratio = 5.07; 95% confidence interval = 1.24-20.65; = 0.023).
The vaginal form of the progesterone could increase the chance of pregnancy and the outcome of fertility (live birth). Thus, vaginal progesterone is effective for LPS in women undergoing fresh embryo transfer.
黄体期孕酮缺乏是早产和复发性流产的原因之一。本研究的目的是比较口服地屈孕酮和阴道用孕酮在辅助生殖技术周期（ART）中进行黄体期支持（LPS）的效果。
本随机临床对照试验研究对207名不孕妇女进行。样本被随机分为两组。第一组每天一次接受400毫克天然微粒化阴道孕酮（MVP），第二组每天两次接受20毫克地屈孕酮（达芙通）。然后比较两组的化学妊娠、流产和活产情况。
研究结果表明，与口服形式相比，药物的阴道形式可增加怀孕几率（β-人绒毛膜促性腺激素阳性）。根据在调整其他变量后的多元逻辑回归分析结果，阴道组的活产率是口服组的五倍多（优势比=5.07；95%置信区间=1.24-20.65；P=0.023）。
孕酮的阴道形式可增加怀孕几率和生育结局（活产）。因此，阴道孕酮对接受新鲜胚胎移植的妇女进行黄体期支持是有效的。
