Bhalla Sameer, Kuchel George A, Pandol Stephen, Bishehsari Faraz
Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
UConn Center on Aging, University of Connecticut, Farmington, Connecticut.
Gastro Hep Adv. 2022 Mar 30;1(3):344-349. doi: 10.1016/j.gastha.2022.01.007. eCollection 2022.
Fatty infiltration of the pancreas has been shown to be associated with both precancerous pancreatic lesions and pancreatic ductal adenocarcinoma. We aim to determine predictors of fatty infiltration of the pancreas in United States adults.
In this retrospective cohort study conducted at a large academic hospital in Chicago, Illinois, we calculated the relative fatty infiltration of the pancreas (corrected to spleen) of 265 cancer-free individuals based on their cross-sectional imaging. Demographic data and relevant laboratory results were obtained from medical records.
We found that age was the strongest predictor of fatty infiltration of the pancreas in our series ( < .01). Fatty infiltration of the pancreas was also significantly associated with body mass index ( < .01) and hyperlipidemia ( < .05). In women, in addition to age ( < .05), elevated body mass index ( = .023), hyperlipidemia ( = .013), and fatty liver ( = .017) were predictors of fat in pancreas. We found a sex-dependent association between pancreatic fat and metabolic syndrome including fatty liver ( = .002).
Fatty infiltration of the pancreas increases by age and components of metabolic syndrome. These assertions could be sex-dependent.
胰腺脂肪浸润已被证明与癌前胰腺病变及胰腺导管腺癌均有关联。我们旨在确定美国成年人胰腺脂肪浸润的预测因素。
在伊利诺伊州芝加哥市一家大型学术医院进行的这项回顾性队列研究中，我们根据265名无癌个体的横断面成像计算了胰腺（校正至脾脏）的相对脂肪浸润情况。人口统计学数据和相关实验室结果从病历中获取。
我们发现年龄是本研究系列中胰腺脂肪浸润的最强预测因素（<0.01）。胰腺脂肪浸润也与体重指数（<0.01）和高脂血症（<0.05）显著相关。在女性中，除年龄外（<0.05），体重指数升高（=0.023）、高脂血症（=0.013）和脂肪肝（=0.017）也是胰腺脂肪的预测因素。我们发现胰腺脂肪与包括脂肪肝在内的代谢综合征之间存在性别依赖性关联（=0.002）。
胰腺脂肪浸润随年龄增长及代谢综合征各组分增加而增加。这些论断可能存在性别依赖性。
