Muller Tamlynn Lynette, Van Der Merwe Kevin, Steele Chris, Papanikolaou Maria, O'Dowd Gerry, Parihar Vikrant
Department of Internal Medicine, Letterkenny University Hospital, Letterkenny Co. Donegal, Ireland.
Department of Gastroenterology, Letterkenny University Hospital, Letterkenny Co. Donegal, Ireland.
Gastro Hep Adv. 2022 Apr 2;1(3):417-419. doi: 10.1016/j.gastha.2022.02.001. eCollection 2022.
Eosinophilic gastrointestinal disorders produce gastrointestinal dysfunction as eosinophils accumulate throughout gastrointestinal tissues. The majority of eosinophilic gastrointestinal disorders are a diagnosis of exclusion, and a magnitude of differentials must be considered. A history of anaphylaxis raises the suspicion that systemic mastocytosis (SM) is the foremost differential to be considered. SM (hematological neoplasm) is characterized by the accumulation of clonal mast cells in systemic tissues that causes gastrointestinal manifestations. In these rare cases, serum tryptase and tissue staining for c-kit/CD117 (an immunohistochemical marker of mast cells) will clinch the diagnosis. Gastrointestinal manifestations of SM are expeditiously resolved with combined oral antihistamines.
嗜酸性胃肠道疾病会导致胃肠功能障碍，因为嗜酸性粒细胞会在整个胃肠道组织中积聚。大多数嗜酸性胃肠道疾病是排除性诊断，必须考虑一系列不同的鉴别诊断。过敏反应病史会增加对系统性肥大细胞增多症（SM）的怀疑，这是首先要考虑的鉴别诊断。SM（血液系统肿瘤）的特征是克隆性肥大细胞在全身组织中积聚，从而导致胃肠道表现。在这些罕见病例中，血清类胰蛋白酶和c-kit/CD117（肥大细胞的免疫组化标志物）组织染色将确诊该病。联合口服抗组胺药可迅速缓解SM的胃肠道表现。
