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Single-center Clinical Experience of Diarrhea in Patients Treated With Sorafenib Shows Rare Development of Pancreatic Atrophy.

作者信息

BouSaba J, Magnus Y, Sannaa W, Camilleri M

机构信息

Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.

出版信息

Gastro Hep Adv. 2022 Mar 30;1(3):296-298. doi: 10.1016/j.gastha.2021.12.013. eCollection 2022.

DOI:10.1016/j.gastha.2021.12.013
PMID:39131687
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11308654/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db1/11308654/243031e5ce45/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db1/11308654/243031e5ce45/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4db1/11308654/243031e5ce45/gr1.jpg

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Single-center Clinical Experience of Diarrhea in Patients Treated With Sorafenib Shows Rare Development of Pancreatic Atrophy.索拉非尼治疗患者腹泻的单中心临床经验显示胰腺萎缩的发生率很低。
Gastro Hep Adv. 2022 Mar 30;1(3):296-298. doi: 10.1016/j.gastha.2021.12.013. eCollection 2022.
2
Long-term therapy with sorafenib is associated with pancreatic atrophy.索拉非尼的长期治疗与胰腺萎缩有关。
J Surg Res. 2015 Dec;199(2):314-21. doi: 10.1016/j.jss.2015.04.035. Epub 2015 Jun 2.
3
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Pancreatic atrophy--a new late toxic effect of sorafenib.胰腺萎缩——索拉非尼一种新的晚期毒性作用。
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本文引用的文献

1
Pancreatic Insufficiency in Patients Under Sorafenib Treatment for Hepatocellular Carcinoma.索拉非尼治疗肝细胞癌患者的胰腺功能不全。
J Clin Gastroenterol. 2021 Mar 1;55(3):263-270. doi: 10.1097/MCG.0000000000001366.
2
Organ Atrophy Induced by Sorafenib and Sunitinib - Quantitative Computed Tomography (CT) Evaluation of the Pancreas, Thyroid Gland and Spleen.索拉非尼和舒尼替尼所致器官萎缩——胰腺、甲状腺和脾脏的定量计算机断层扫描(CT)评估
Pol J Radiol. 2016 Nov 22;81:557-565. doi: 10.12659/PJR.898936. eCollection 2016.
3
Influence of Sorafenib and Bevacizumab on pancreatic volume - A monocentric CT based analysis.
索拉非尼和贝伐单抗对胰腺体积的影响——基于单中心CT的分析
Pancreatology. 2016 Jul-Aug;16(4):621-4. doi: 10.1016/j.pan.2016.02.010. Epub 2016 Feb 27.
4
Pancreatic atrophy--a new late toxic effect of sorafenib.胰腺萎缩——索拉非尼一种新的晚期毒性作用。
N Engl J Med. 2013 Oct 10;369(15):1475-6. doi: 10.1056/NEJMc1305302.
5
Sorafenib-induced diarrhea and hypophosphatemia: mechanisms and therapeutic implications.索拉非尼诱导的腹泻和低磷血症:机制及治疗意义
Ann Oncol. 2012 Jan;23(1):280-281. doi: 10.1093/annonc/mdr525. Epub 2011 Nov 4.
6
Development of second-generation VEGFR tyrosine kinase inhibitors: current status.第二代 VEGFR 酪氨酸激酶抑制剂的开发:现状。
Curr Oncol Rep. 2011 Apr;13(2):103-11. doi: 10.1007/s11912-011-0154-3.
7
Drug therapy: sorafenib.药物治疗:索拉非尼。
Hepatology. 2010 May;51(5):1843-9. doi: 10.1002/hep.23676.
8
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models.索拉非尼(BAY 43 - 9006)在肾细胞癌异种移植模型中可抑制肿瘤生长和血管生成,并诱导肿瘤凋亡和缺氧。
Cancer Chemother Pharmacol. 2007 Apr;59(5):561-74. doi: 10.1007/s00280-006-0393-4. Epub 2006 Dec 8.
9
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.BAY 43 - 9006具有广谱口服抗肿瘤活性,作用于参与肿瘤进展和血管生成的RAF/MEK/ERK信号通路及受体酪氨酸激酶。
Cancer Res. 2004 Oct 1;64(19):7099-109. doi: 10.1158/0008-5472.CAN-04-1443.