SRM Medical College Hospital and Research Centre, Department of Nephrology, Chengalpattu, India.
J Bras Nefrol. 2024 Jul-Sep;46(3):e20240022. doi: 10.1590/2175-8239-JBN-2024-0022en.
Hashimoto's thyroiditis manifesting as hypothyroidism has been implicated in glomerular disorders due to autoantibody formation. Here we present the case of a 26-year-old male without any comorbidities presenting with easy fatiguability and weight gain for 2 months. He was found to have a creatinine of 2.1 mg/dL with a history of rhinitis treated with anti-histaminic three days prior to the hospital visit. He had symptoms of intermittent myalgia for the past two weeks. On laboratory evaluation, he was found to have raised CPK, elevated TSH, low normal T4, and positive anti-TPO and anti-Tg antibodies. Neck ultrasound revealed linear echogenic septations in the thyroid gland. Renal biopsy revealed acute tubular injury. Appropriate thyroxine supplementation was started and his creatinine decreased to 1.2 mg/dL after 1 month. It is important that clinicians should be aware of this rare kidney presentation in Hashimoto's thyroiditis.
桥本甲状腺炎引起的甲状腺功能减退症可因自身抗体的形成而导致肾小球疾病。我们在此报告一例 26 岁男性病例,无任何合并症,表现为易疲劳和体重增加 2 个月。他在就诊前三天因鼻炎接受抗组胺治疗,发现肌酐为 2.1mg/dL。过去两周他有间歇性肌肉疼痛的症状。实验室检查发现肌酸激酶升高,促甲状腺激素升高,甲状腺素正常低值,抗甲状腺过氧化物酶抗体和抗甲状腺球蛋白抗体阳性。颈部超声显示甲状腺线性强回声分隔。肾活检显示急性肾小管损伤。开始适当补充甲状腺素,1 个月后肌酐降至 1.2mg/dL。重要的是,临床医生应该意识到桥本甲状腺炎的这种罕见肾脏表现。