Department of Civil, Construction and Environmental Engineering, University of Alabama, Tuscaloosa, AL, USA.
Department of Medicinal Chemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran.
J Microencapsul. 2024 Nov;41(7):649-678. doi: 10.1080/02652048.2024.2389136. Epub 2024 Aug 12.
This study examines microencapsulation as a method to enhance the stability of natural compounds, which typically suffer from inherent instability under environmental conditions, aiming to extend their application in the pharmaceutical industry.
We explore and compare various microencapsulation techniques, including spray drying, freeze drying, and coacervation, with a focus on spray drying due to its noted advantages.
The analysis reveals that microencapsulation, especially via spray drying, significantly improves natural compounds' stability, offering varied morphologies, sizes, and efficiencies in encapsulation. These advancements facilitate controlled release, taste modification, protection from degradation, and extended shelf life of pharmaceutical products.
Microencapsulation, particularly through spray drying, presents a viable solution to the instability of natural compounds, broadening their application in pharmaceuticals by enhancing protection and shelf life.
本研究考察了微胶囊化作为一种提高天然化合物稳定性的方法，因为天然化合物在环境条件下通常存在固有不稳定性，旨在扩展它们在制药行业的应用。
我们探索并比较了各种微胶囊化技术，包括喷雾干燥、冷冻干燥和凝聚，由于喷雾干燥具有显著的优势，因此重点关注喷雾干燥。
分析表明，微胶囊化，特别是通过喷雾干燥，显著提高了天然化合物的稳定性，提供了各种形态、大小和封装效率。这些进展促进了药物产品的控制释放、口味修饰、防止降解和延长保质期。
微胶囊化，特别是通过喷雾干燥，为天然化合物的不稳定性提供了可行的解决方案，通过增强保护和延长保质期，拓宽了它们在制药领域的应用。
