Sousa-Neto Sebastião Silvério, Pereira Gimenna Barbosa, Mendonça Elismauro Francisco, Martins Allisson Filipe Lopes
Universidade Evangélica de Goiás, Department of Oral Diagnosis, Avenida Universitária, Km 3, 5, s/n, Cidade Universitária, Anápolis, Goiás, Brazil. ZIP-code: 75083-515.
Stomatologija. 2023;25(4):91-96.
The central giant cell lesion (CGCL) is a benign intraosseous lesion that may resemble other giant cell-rich lesions, such as the peripheral giant cell lesion (PGCL). This lesion may be classified as aggressive or non-aggressive according to clinical and radiographic criteria, however, there is no biological marker that may help to define the CGCL based on the biological behavior. In this context, stromal cell phagocytosis has been described as an event related to aggressive lesions, however, only a few studies have investigated this phenomenon in CGCL. The aim of this study was to compare mononuclear cell phagocytosis by the multinucleated giant cells between aggressive, non-aggressive CGCL and PGCL.
Thirty-three cases of CGCL, 10 aggressive and 23 non-aggressive, and 20 cases of PGCL were included in this study. Phagocytosis events were evaluated in five consecutive microscopic fields from histological sections, stained with hematoxylin and eosin. The ratio between the numbers of phagocytosis/mmand the total number of multinucleated giant cells/mmwas calculated.
Phagocytosis was observed in the multinucleated giant cells of all cases. The density of phagocytosis/mmin relation to giant cells/mmwas higher in the CGCL than in the PGCL. In addition, aggressive CGCL showed higher phagocytosis events when compared to the non-aggressive variant.
Our results suggest that the aggressiveness of multinucleated giant cell lesions of the jaws may be related to the number of phagocytosis events in the lesion.
中央巨细胞病变（CGCL）是一种良性骨内病变，可能类似于其他富含巨细胞的病变，如外周巨细胞病变（PGCL）。根据临床和影像学标准，该病变可分为侵袭性或非侵袭性，然而，尚无生物学标志物可根据生物学行为来定义CGCL。在此背景下，基质细胞吞噬作用已被描述为与侵袭性病变相关的事件，然而，仅有少数研究在CGCL中调查了这一现象。本研究的目的是比较侵袭性、非侵袭性CGCL和PGCL中多核巨细胞的单核细胞吞噬作用。
本研究纳入33例CGCL病例，其中10例为侵袭性，23例为非侵袭性，以及20例PGCL病例。在苏木精和伊红染色的组织切片的连续五个显微镜视野中评估吞噬事件。计算吞噬作用数量/mm与多核巨细胞总数/mm的比值。
在所有病例的多核巨细胞中均观察到吞噬作用。与PGCL相比，CGCL中吞噬作用/mm与巨细胞/mm的密度更高。此外，与非侵袭性变体相比，侵袭性CGCL显示出更高的吞噬事件。
我们的结果表明，颌骨多核巨细胞病变的侵袭性可能与病变中吞噬事件的数量有关。
