Institute of Functional Genomics, University of Montpellier, CNRS, INSERM , Montpellier, France.
Institute of Biochemistry of the Romanian Academy , Bucharest, Romania.
J Cell Biol. 2024 Sep 2;223(9). doi: 10.1083/jcb.202404152. Epub 2024 Aug 12.
Most secreted proteins are transported through the "conventional" endoplasmic reticulum-Golgi apparatus exocytic route for their delivery to the cell surface and release into the extracellular space. Nonetheless, formative discoveries have underscored the existence of alternative or "unconventional" secretory routes, which play a crucial role in exporting a diverse array of cytosolic proteins outside the cell in response to intrinsic demands, external cues, and environmental changes. In this context, lysosomes emerge as dynamic organelles positioned at the crossroads of multiple intracellular trafficking pathways, endowed with the capacity to fuse with the plasma membrane and recognized for their key role in both conventional and unconventional protein secretion. The recent recognition of lysosomal transport and exocytosis in the unconventional secretion of cargo proteins provides new and promising insights into our understanding of numerous physiological processes.
大多数分泌蛋白通过“经典”的内质网-高尔基体胞吐途径运输，以将其递送到细胞表面并释放到细胞外空间。尽管如此，一些开创性的发现强调了替代或“非常规”分泌途径的存在，这些途径在响应内在需求、外部信号和环境变化时，对于将各种细胞质蛋白输出到细胞外发挥着关键作用。在这种情况下，溶酶体作为位于多种细胞内运输途径交汇点的动态细胞器出现，具有与质膜融合的能力，并因其在常规和非常规蛋白分泌中的关键作用而得到认可。最近在货物蛋白非常规分泌中对溶酶体运输和胞吐作用的认识，为我们理解许多生理过程提供了新的、有前景的见解。
