Li Shiyun, An Yan, Zhao Wei, Huang Jun, Wen Bin, Chen Xingquan
Qingyuan Innovation Laboratory, Quanzhou 362801, China.
College of Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
Org Lett. 2024 Aug 23;26(33):6988-6992. doi: 10.1021/acs.orglett.4c02315. Epub 2024 Aug 12.
In this paper, a highly efficient copper-catalyzed oxidative dehydrogenative coupling to obtain benzo[]cinnolines (up to 100% yield) was developed. It was found that DMAP was a highly efficient ligand for copper-catalyzed oxidation, and molecular oxygen was a green oxidizing agent. In this simple process, various functional groups were tolerated under mild reaction conditions, and the practicality of the process was demonstrated by the preparation of benzo[]cinnolines on a gram scale and later derivatization.
本文报道了一种高效的铜催化氧化脱氢偶联反应，用于制备苯并[c]噌啉（产率高达100%）。研究发现，4-二甲氨基吡啶（DMAP）是铜催化氧化反应的高效配体，分子氧是一种绿色氧化剂。在这个简单的过程中，各种官能团在温和的反应条件下都能兼容，并且通过克级规模制备苯并[c]噌啉及其后续衍生化反应证明了该方法的实用性。
