Hagino Teppei, Onda Marina, Saeki Hidehisa, Fujimoto Eita, Kanda Naoko
Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
Department of Dermatology, Nippon Medical School, Tokyo, Japan.
J Dermatol. 2024 Dec;51(12):1658-1664. doi: 10.1111/1346-8138.17427. Epub 2024 Aug 12.
Psoriasis is a complex, chronic inflammatory skin disease that significantly impacts patients' quality of life (QOL), especially in cases of genital, nail, and scalp psoriasis. Bimekizumab is an inhibitor of interleukin (IL)-17A and IL-17F and used for the treatment of psoriasis. The aim of this retrospective study was to evaluate the effectiveness of bimekizumab through in treating genital, nail, and scalp lesions with psoriasis over 24 weeks. The study was conducted from May 2022 and February 2024 on 52 psoriasis patients treated with bimekizumab. The therapeutic effects of bimekizumab were evaluated by the achievement of Physician's Global Assessment (PGA) rates of 0/1 on the genitals (genital-PGA), fingernails (PGA-F), scalp-specific PGA (ss-PGA), static PGA (sPGA), and the Dermatology Life Quality Index (DLQI) at weeks 4, 16, and 24. Bimekizumab treatment significantly improved genital, nail, and scalp lesions with psoriasis. At week 24, the achievement rate of genital-PGA 0/1, PGA-F 0/1, ss-PGA 0/1 was 96.2%, 66.7%, or 93.9%, and that of sPGA 0/1 or DLQI 0/1 was 93.9% or 83.3%, respectively. Bimekizumab was effective for genital, nail, and scalp lesions with psoriasis, difficult-to-treat lesions, and simultaneously improved QOL in a real-world clinical practice.
银屑病是一种复杂的慢性炎症性皮肤病，严重影响患者的生活质量（QOL），尤其是在生殖器、指甲和头皮银屑病病例中。比美吉珠单抗是一种白细胞介素（IL）-17A和IL-17F抑制剂，用于治疗银屑病。这项回顾性研究的目的是评估比美吉珠单抗在治疗24周以上的生殖器、指甲和头皮银屑病病变中的有效性。该研究于2022年5月至2024年2月对52例接受比美吉珠单抗治疗的银屑病患者进行。在第4、16和24周，通过生殖器（生殖器-PGA）、指甲（PGA-F）、头皮特异性PGA（ss-PGA）、静态PGA（sPGA）达到0/1的医师整体评估（PGA）率以及皮肤病生活质量指数（DLQI）来评估比美吉珠单抗的治疗效果。比美吉珠单抗治疗显著改善了银屑病的生殖器、指甲和头皮病变。在第24周时，生殖器-PGA 0/1、PGA-F 0/1、ss-PGA 0/1的达成率分别为96.2%、66.7%或93.9%，sPGA 0/1或DLQI 0/1的达成率分别为93.9%或83.3%。在真实世界的临床实践中，比美吉珠单抗对银屑病的生殖器、指甲和头皮病变、难治性病变有效，并同时改善了生活质量。
