School of Pharmacy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Endocrinology. 2024 Aug 27;165(10). doi: 10.1210/endocr/bqae104.
The phosphorylation of the transmembrane protein nephrin has been shown to play an important role in signaling in kidney podocytes, and it has now been shown to also play a key role in regulating pancreatic β-cell function. Williamson et al have recently shown that the loss of nephrin tyrosine phosphorylation on its 3 cytoplasmic YDxV motifs can enhance insulin release in aged female mice. These studies suggest that blocking nephrin phosphorylation may be an effective treatment option for improving β-cell function.
跨膜蛋白 Nephrin 的磷酸化已被证明在肾脏足细胞信号转导中发挥重要作用，现在也被证明在调节胰腺β细胞功能方面发挥关键作用。Williamson 等人最近表明，在年老雌性小鼠中，Nephrin 的 3 个细胞质 YDxV 基序的酪氨酸磷酸化丧失可以增强胰岛素的释放。这些研究表明，阻断 Nephrin 的磷酸化可能是改善β细胞功能的有效治疗选择。
