• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Results of International, Double-Blind, Randomized, Placebo-Controlled, Phase IIa Study of Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment-Elevation Myocardial Infarction (STEMI).

作者信息

Abbate Antonio, Van Tassell Benjamin, Bogin Vlad, Markley Roshanak, Pevzner Dmitry V, Cremer Paul C, Meray Imad, Privalov Dmitry V, Taylor Angela, Grishin Sergey A, Egorova Alina N, Ponomar Ekaterina G, Lavrovsky Yan, Samsonov Mikhail Yu

机构信息

Department of Medicine, University of Virginia, Charlottesville (A.A., A.T.).

Department of Internal Medicine, Virginia Commonwealth University, Richmond (B.V.T., R.M.).

出版信息

Circulation. 2024 Aug 13;150(7):580-582. doi: 10.1161/CIRCULATIONAHA.124.069396. Epub 2024 Aug 12.

DOI:10.1161/CIRCULATIONAHA.124.069396
PMID:39133774
Abstract
摘要

相似文献

1
Results of International, Double-Blind, Randomized, Placebo-Controlled, Phase IIa Study of Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment-Elevation Myocardial Infarction (STEMI).RPH-104（戈弗利西普）对白介素-1进行阻断治疗ST段抬高型心肌梗死（STEMI）患者的国际、双盲、随机、安慰剂对照IIa期研究结果
Circulation. 2024 Aug 13;150(7):580-582. doi: 10.1161/CIRCULATIONAHA.124.069396. Epub 2024 Aug 12.
2
Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment Elevation Myocardial Infarction: Secondary End Points From an International, Double-Blind, Randomized, Placebo-Controlled, Phase 2a Study.RPH-104（戈弗利西普）对ST段抬高型心肌梗死患者进行白细胞介素-1阻断治疗：一项国际、双盲、随机、安慰剂对照的2a期研究的次要终点
J Cardiovasc Pharmacol. 2024 Dec 1;84(6):565-577. doi: 10.1097/FJC.0000000000001635.
3
Interleukin-1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST-Segment-Elevation Myocardial Infarction.白细胞介素-1 阻断剂抑制 ST 段抬高型心肌梗死患者的急性炎症反应。
J Am Heart Assoc. 2020 Mar 3;9(5):e014941. doi: 10.1161/JAHA.119.014941.
4
Interleukin-1 blockade with RPH-104 in patients with acute ST-elevation myocardial infarction: study design and rationale.RPH-104对急性ST段抬高型心肌梗死患者进行白细胞介素-1阻断：研究设计与原理
J Transl Med. 2021 Apr 26;19(1):169. doi: 10.1186/s12967-021-02828-z.
5
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction.白细胞介素 6 受体抑制在急性 ST 段抬高型心肌梗死患者中的随机临床试验。
J Am Coll Cardiol. 2021 Apr 20;77(15):1845-1855. doi: 10.1016/j.jacc.2021.02.049.
6
Rationale and design of the Virginia Commonwealth University-Anakinra Remodeling Trial-3 (VCU-ART3): A randomized, placebo-controlled, double-blinded, multicenter study.弗吉尼亚联邦大学-阿那白滞素重塑试验-3（VCU-ART3）的原理与设计：一项随机、安慰剂对照、双盲、多中心研究。
Clin Cardiol. 2018 Aug;41(8):1004-1008. doi: 10.1002/clc.22988. Epub 2018 Aug 17.
7
High versus low dose statin therapy in Indian patients with acute ST-segment elevation myocardial infarction undergoing thrombolysis.印度急性ST段抬高型心肌梗死溶栓患者高剂量与低剂量他汀类药物治疗对比研究
Indian Heart J. 2017 Jul-Aug;69(4):453-457. doi: 10.1016/j.ihj.2017.05.026. Epub 2017 May 30.
8
Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B.随机、安慰剂对照的 2b 期研究评估重组人卵磷脂胆固醇酰基转移酶在急性 ST 段抬高型心肌梗死中的安全性和疗效：REAL-TIMI 63B 研究结果。
Circulation. 2022 Sep 20;146(12):907-916. doi: 10.1161/CIRCULATIONAHA.122.059325. Epub 2022 Aug 30.
9
MethotrexaTE THerapy in ST-Segment Elevation MYocardial InfarctionS: A Randomized Double-Blind, Placebo-Controlled Trial (TETHYS Trial).甲氨蝶呤治疗ST段抬高型心肌梗死：一项随机双盲、安慰剂对照试验（特提斯试验）
J Cardiovasc Pharmacol Ther. 2017 Nov;22(6):538-545. doi: 10.1177/1074248417699884. Epub 2017 Mar 22.
10
Association between gender and short-term outcome in patients with ST elevation myocardial infraction participating in the international, prospective, randomised Administration of Ticagrelor in the catheterisation Laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery (ATLANTIC) trial: a prespecified analysis.参与国际前瞻性随机试验“替格瑞洛在导管室或救护车上用于新发性ST段抬高型心肌梗死开通冠状动脉（ATLANTIC）试验”的ST段抬高型心肌梗死患者的性别与短期预后之间的关联：一项预先设定的分析。
BMJ Open. 2017 Sep 21;7(9):e015241. doi: 10.1136/bmjopen-2016-015241.

引用本文的文献

1
Inhibition of interleukin-1 or -6 after myocardial infarction: pros, cons, and future perspectives.心肌梗死后白细胞介素-1或白细胞介素-6的抑制作用：利弊及未来展望。
Eur Heart J Cardiovasc Pharmacother. 2025 Jul 7;11(4):321. doi: 10.1093/ehjcvp/pvaf022.
2
Current Drug Treatment for Acute and Recurrent Pericarditis.急性和复发性心包炎的当前药物治疗
Drugs. 2025 May;85(5):643-658. doi: 10.1007/s40265-025-02169-x. Epub 2025 Mar 22.
3
Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment.动脉粥样硬化性心血管疾病中的炎症：从诊断到治疗。
Eur J Clin Invest. 2025 Jul;55(7):e70020. doi: 10.1111/eci.70020. Epub 2025 Mar 8.
4
The Role of Cardiac Troponin and Other Emerging Biomarkers Among Athletes and Beyond: Underlying Mechanisms, Differential Diagnosis, and Guide for Interpretation.心肌肌钙蛋白及其他新兴生物标志物在运动员及其他人群中的作用：潜在机制、鉴别诊断及解读指南
Biomolecules. 2024 Dec 19;14(12):1630. doi: 10.3390/biom14121630.
5
Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment Elevation Myocardial Infarction: Secondary End Points From an International, Double-Blind, Randomized, Placebo-Controlled, Phase 2a Study.RPH-104（戈弗利西普）对ST段抬高型心肌梗死患者进行白细胞介素-1阻断治疗：一项国际、双盲、随机、安慰剂对照的2a期研究的次要终点
J Cardiovasc Pharmacol. 2024 Dec 1;84(6):565-577. doi: 10.1097/FJC.0000000000001635.
6
Novel Therapeutics and Upcoming Clinical Trials Targeting Inflammation in Cardiovascular Diseases.针对心血管疾病炎症的新型治疗方法和即将开展的临床试验。
Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2371-2395. doi: 10.1161/ATVBAHA.124.319980. Epub 2024 Oct 10.