Lilja M, Ikäheimo M, Mattila M J, Jounela A J
Ann Clin Res. 1985;17(6):316-22.
Haemodynamic effects of atenolol 50 mg, clonidine 0.15 mg, and prazosin 5 mg, given twice daily, and of the combinations atenolol + prazosin and clonidine + prazosin were studied in 8 hypertensive outpatients. Measurements were made at rest, during isometric sustained handgrip and submaximal ergometer work in mostly double-blind and cross-over fashion. Given individually atenolol and prazosin lowered resting supine blood pressure. The addition of prazosin increased the antihypertensive effects of atenolol but not of clonidine. At the end of the isometric exercise atenolol and prazosin given alone both lowered diastolic blood pressure as compared to respective pretreatment values. During handgrip prazosin contributed a little, but not much, to the antihypertensive effects of atenolol and clonidine. During dynamic exercise atenolol, clonidine, and prazosin given alone each lowered blood pressure, prazosin decreasing diastolic blood pressure in particular. Prazosin added to the antihypertensive effect of atenolol more than that of clonidine. Echocardiographic measurements revealed no significant differences between treatments at rest. During handgrip the mean velocity of left ventricular circumferential muscle fibre shortening was reduced by atenolol as compared to pretreatment values. We conclude that atenolol + prazosin may help the patients to maintain adequate haemodynamics during daily physical stresses whilst the combination prazosin + clonidine may not offer any particular advantages.
对8名高血压门诊患者研究了每日两次服用50毫克阿替洛尔、0.15毫克可乐定和5毫克哌唑嗪以及阿替洛尔+哌唑嗪和可乐定+哌唑嗪组合的血流动力学效应。测量在静息状态下、等长持续握力期间以及次极量测力计运动期间进行，大多采用双盲和交叉方式。单独给予阿替洛尔和哌唑嗪可降低静息仰卧血压。添加哌唑嗪可增强阿替洛尔的降压效果，但对可乐定无此作用。在等长运动结束时，与各自的预处理值相比，单独给予阿替洛尔和哌唑嗪均降低了舒张压。在握力期间，哌唑嗪对阿替洛尔和可乐定的降压作用贡献不大。在动态运动期间，单独给予阿替洛尔、可乐定和哌唑嗪均可降低血压，哌唑嗪尤其能降低舒张压。哌唑嗪对阿替洛尔降压作用的增强超过对可乐定的增强。超声心动图测量显示静息时各治疗组之间无显著差异。在握力期间，与预处理值相比，阿替洛尔使左心室圆周肌纤维缩短的平均速度降低。我们得出结论，阿替洛尔+哌唑嗪可能有助于患者在日常身体应激期间维持足够的血流动力学，而哌唑嗪+可乐定组合可能没有任何特别优势。
