Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100000, China; Department of Dermatology, North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China.
Clinical Medical College, North China University of Science and Technology, Tangshan, 063210, China.
Biochem Biophys Res Commun. 2024 Dec 10;737:150523. doi: 10.1016/j.bbrc.2024.150523. Epub 2024 Aug 8.
Rosacea, a prevalent chronic facial inflammatory condition, afflicts millions worldwide. Its multifaceted pathogenesis poses challenges for effective treatment. Tranilast (TR), an analog of a tryptophan metabolite, has demonstrated anti-inflammatory and anti-fibrotic properties across various diseases. Yet, its potential in rosacea treatment remains understudied. Here, we induced rosacea-like symptoms in mice via prolonged LL-37 injections and administered TR intervention. Our findings reveal that TR mitigated skin lesions, reduced skin thickness, and suppressed inflammatory cell infiltration within the dermis of LL-37 mice. Notably, TR downregulated the expression of rosacea-associated inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-18) and the antimicrobial peptide CAMP, while also inhibiting NLRP3 inflammasome activation and the TLR4 signaling pathway. Furthermore, TR attenuated LL-37-induced fibrosis and hindered the transforming growth factor-β1 (TGF-β1)/Smad2/3 pathway. In summary, our study underscores TR's therapeutic potential in rosacea by mitigating both skin inflammation and fibrosis, thereby offering a promising treatment avenue for this condition.
酒渣鼻，一种常见的慢性面部炎症性疾病，影响着全球数百万人。其多方面的发病机制给有效治疗带来了挑战。曲尼司特（TR）是色氨酸代谢物的类似物，在多种疾病中表现出抗炎和抗纤维化特性。然而，其在酒渣鼻治疗中的潜力仍有待研究。在这里，我们通过长时间注射 LL-37 诱导小鼠出现酒渣鼻样症状，并进行 TR 干预。我们的研究结果表明，TR 减轻了皮肤损伤，降低了皮肤厚度，并抑制了 LL-37 小鼠真皮内炎症细胞的浸润。值得注意的是，TR 下调了与酒渣鼻相关的炎症细胞因子（TNF-α、IL-6、IL-1β 和 IL-18）和抗菌肽 CAMP 的表达，同时抑制了 NLRP3 炎性体激活和 TLR4 信号通路。此外，TR 减轻了 LL-37 诱导的纤维化，并抑制了转化生长因子-β1（TGF-β1）/Smad2/3 通路。总之，我们的研究强调了 TR 通过减轻皮肤炎症和纤维化在酒渣鼻治疗中的潜在治疗作用，为这种疾病提供了一种有前途的治疗途径。
