Aydin Hilal, Baykan Ozgür
Department of Pediatrics, Faculty of Medicine, Balikesir University, Balikesir, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Balikesir University, Balikesir, Turkey.
Neuropediatrics. 2025 Feb;56(1):29-33. doi: 10.1055/s-0044-1788787. Epub 2024 Aug 12.
Very few studies have examined the relationship between calcitonin gene-related peptide (CGRP) and amylin levels and the disease in patients with migraine. The purpose of this study was to compare blood CGRP and amylin levels between pediatric migraine patients and healthy controls and the relationship between CGRP and amylin levels and migraine attack frequency and duration.
The study involved two separate groups-control and migraine. Thirty-two patients aged 6 to 18 years presenting to the Balikesir University Medical Faculty pediatric neurology clinic and diagnosed with migraine were included. The control group consisted of 32 patients without migraine presenting to the clinic during the same time frame. The patients' demographic data, personal and family histories, migraine type and frequency, headache severity, basic anthropometric measurements (height, weight, and body mass index), and physical and neurological examination findings were recorded. Migraine patients were classified as ictal if the collection of blood specimens coincided with the attack period and as interictal if this was performed between attacks.
No statistically significant differences in mean CGRP or amylin levels were determined between the groups (migraine ictal/interictal) or between the migraine patients (in terms of gender or attack frequency and duration).
Elucidating the complex processes involved in the pathogenesis of migraine is important in terms of our ability to develop new treatments and therapeutic strategies. This study aimed to evaluate CGRP and amylin levels in patients with pediatric migraine (in the ictal and interictal periods) compared with those in healthy controls.
很少有研究探讨降钙素基因相关肽（CGRP）和胰淀素水平与偏头痛患者疾病之间的关系。本研究的目的是比较儿童偏头痛患者与健康对照者的血液CGRP和胰淀素水平，以及CGRP和胰淀素水平与偏头痛发作频率和持续时间之间的关系。
该研究包括两个独立的组——对照组和偏头痛组。纳入了32名年龄在6至18岁之间、到巴勒克埃西尔大学医学院儿科神经科门诊就诊并被诊断为偏头痛的患者。对照组由32名在同一时间段到门诊就诊但无偏头痛的患者组成。记录患者的人口统计学数据、个人和家族病史、偏头痛类型和频率、头痛严重程度、基本人体测量指标（身高、体重和体重指数）以及体格和神经系统检查结果。偏头痛患者若血液标本采集时间与发作期重合则分类为发作期，若在发作间期采集则分类为发作间期。
在各组（偏头痛发作期/发作间期）之间或偏头痛患者之间（就性别或发作频率和持续时间而言），未确定平均CGRP或胰淀素水平存在统计学上的显著差异。
就我们开发新治疗方法和治疗策略的能力而言，阐明偏头痛发病机制中涉及的复杂过程很重要。本研究旨在评估儿童偏头痛患者（发作期和发作间期）与健康对照者相比的CGRP和胰淀素水平。
