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Induction of sustained remission and reversal of pathologic transcriptome achieved with tezepelumab in an adolescent with eosinophilic esophagitis.

作者信息

Sharlin Colby S, Collins Margaret H, Bolton Scott M, Osswald Garrett A, Safadi Ghassan S, Kliewer Kara L, Rothenberg Marc E, Shoda Tetsuo, Mukkada Vincent A

机构信息

Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

J Allergy Clin Immunol Pract. 2024 Nov;12(11):3147-3149.e2. doi: 10.1016/j.jaip.2024.08.013. Epub 2024 Aug 10.

DOI:10.1016/j.jaip.2024.08.013
PMID:39134146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11560512/
Abstract
摘要

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本文引用的文献

1
TSLP shapes the pathogenic responses of memory CD4 T cells in eosinophilic esophagitis.TSLP 塑造嗜酸性食管炎中记忆性 CD4 T 细胞的致病反应。
Sci Signal. 2023 Sep 12;16(802):eadg6360. doi: 10.1126/scisignal.adg6360.
2
Role of thymic stromal lymphopoietin in allergy and beyond.胸腺基质淋巴细胞生成素在过敏及其他疾病中的作用
Nat Rev Immunol. 2023 Jan;23(1):24-37. doi: 10.1038/s41577-022-00735-y. Epub 2022 Jun 1.
3
Eosinophilic Esophagitis: A Review.嗜酸性粒细胞性食管炎：综述。
JAMA. 2021 Oct 5;326(13):1310-1318. doi: 10.1001/jama.2021.14920.
4
Diagnostic merits of the Eosinophilic Esophagitis Diagnostic Panel from a single esophageal biopsy.单个食管活组织检查的嗜酸性食管炎诊断试剂盒的诊断价值。
J Allergy Clin Immunol. 2022 Feb;149(2):782-787.e1. doi: 10.1016/j.jaci.2021.07.032. Epub 2021 Aug 8.
5
Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.特泽布尔单抗在成人和青少年重症、未控制哮喘中的应用。
N Engl J Med. 2021 May 13;384(19):1800-1809. doi: 10.1056/NEJMoa2034975.
6
Eosinophilic Esophagitis Reference Score Accurately Identifies Disease Activity and Treatment Effects in Children.嗜酸性粒细胞性食管炎参考评分准确识别儿童疾病活动度和治疗效果。
Clin Gastroenterol Hepatol. 2018 Jul;16(7):1056-1063. doi: 10.1016/j.cgh.2017.12.019. Epub 2017 Dec 15.
7
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.新开发并经验证的嗜酸性食管炎组织学评分系统及其在疾病诊断和监测方面优于嗜酸性粒细胞峰值计数的证据。
Dis Esophagus. 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470.
8
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.胸腺基质淋巴细胞生成素诱导的嗜碱性粒细胞反应促进嗜酸性食管炎。
Nat Med. 2013 Aug;19(8):1005-13. doi: 10.1038/nm.3281. Epub 2013 Jul 21.