Chest Department, Hôpital Universitaire de Bruxelles Erasme, Université Libre de Bruxelles, Brussels, Belgium; European Plotkin Institute for Vaccinology, Université Libre de Bruxelles, Brussels, Belgium.
European Plotkin Institute for Vaccinology, Université Libre de Bruxelles, Brussels, Belgium; Department of Nephrology, Dialysis and Transplantation, Hôpital Universitaire de Bruxelles Erasme, Université Libre de Bruxelles, Brussels, Belgium.
J Heart Lung Transplant. 2024 Nov;43(11):1857-1860. doi: 10.1016/j.healun.2024.08.002. Epub 2024 Aug 10.
Lung transplant recipients (LTRs) are susceptible to severe Coronavirus Disease 2019 (COVID-19) and had lower immune responses to primary severe acute respiratory syndrome-related to coronavirus 2 (SARS-CoV-2) vaccination as compared to the general population and to other solid organ transplant recipients. As immunity induced by booster vaccination and natural infection has increased since the beginning of the pandemic in the general population, immunity acquired by LTRs is not well documented. Humoral and cellular immunity to SARS-CoV-2 was monitored in February and May 2023 in 30 LTRs and compared to that of health care workers (HCWs) and nursing home residents (NHRs). LTRs had significantly lower levels of SARS-CoV-2 binding and neutralizing antibodies and lower interferon-gamma responses to Wuhan, Delta, and XBB1.5 variants as compared to HCWs and NHRs. Humoral immunity decreased between the 2 visits, whereas cellular immunity remained more stable. The persistent defect in SARS-CoV-2 immunity in LTRs should encourage continued monitoring and preventive measures for this vulnerable population.
肺移植受者（LTR）易感染严重的 2019 年冠状病毒病（COVID-19），并且与一般人群和其他实体器官移植受者相比，对原发性严重急性呼吸综合征相关冠状病毒 2（SARS-CoV-2）疫苗的免疫反应较低。由于自大流行开始以来，普通人群中由加强疫苗接种和自然感染引起的免疫反应有所增加，因此 LTR 获得的免疫反应尚未得到很好的记录。在 2023 年 2 月和 5 月监测了 30 名 LTR 对 SARS-CoV-2 的体液和细胞免疫，并将其与医护人员（HCWs）和养老院居民（NHRs）进行了比较。与 HCWs 和 NHRs 相比，LTR 对武汉、Delta 和 XBB1.5 变体的 SARS-CoV-2 结合和中和抗体水平以及干扰素-γ反应明显较低。体液免疫在两次就诊之间下降，而细胞免疫保持更稳定。LTR 中 SARS-CoV-2 免疫的持续缺陷应鼓励对这一脆弱人群进行持续监测和预防措施。
