在小鼠的低电流丘脑深部脑刺激期间出现电发作。
Electrographic seizures during low-current thalamic deep brain stimulation in mice.
机构信息
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, 02114, MA, USA; Center for Brains, Minds, and Machines, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA.
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, 02114, MA, USA; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA.
出版信息
Brain Stimul. 2024 Sep-Oct;17(5):975-979. doi: 10.1016/j.brs.2024.08.002. Epub 2024 Aug 10.
BACKGROUND
Deep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT).
OBJECTIVES
To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice.
METHODS
Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration.
RESULTS
In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 μA.
CONCLUSION
Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.
背景
丘脑中央深部脑刺激（CT-DBS）具有调节意识状态的潜力，但也可能引发电癫痫发作，包括多棘波-尖波（PSWT）。
目的
报告在清醒、自由活动的小鼠中进行 CT-DBS 时诱导 PSWT 的概率。
方法
将电极植入小鼠体内，以不同频率进行单侧和双侧 CT-DBS 刺激，同时记录脑电图（EEG）。我们通过在每个频率逐渐增加刺激电流来滴定刺激电流，直到出现 PSWT。随后在滴定过程中引起 PSWT 的电流下一级进行刺激，以测试觉醒调节。
结果
在 2.21%的测试刺激中（12 只小鼠中有 10 只），CT-DBS 在低于滴定电流的电流下引起 PSWT，包括低至 20 μA 的电流。
结论
即使在滴定后和相对较低的电流下，我们的研究也发现了诱导 PSWT 的小但显著的概率。在研究和临床环境中进行 CT-DBS 时，应密切监测脑电图以检测电癫痫发作。
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