Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, 130041 Jilin, China.
Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, 130041 Jilin, China.
Cell Signal. 2024 Oct;122:111345. doi: 10.1016/j.cellsig.2024.111345. Epub 2024 Aug 10.
In tumors, the rapid proliferation of cells and the imperfect blood supply system lead to hypoxia, which can regulate the adaptation of tumor cells to the hypoxic environment through hypoxia-inducible factor-1α (HIF-1α) and promote tumor development in multiple ways. Recent studies have found that epithelial-mesenchymal transition (EMT) and ferroptosis play important roles in the progression of tumor cells. The activation of HIF-1α is considered a key factor in inducing EMT in tumor cells. When HIF-1α is activated, it can regulate EMT-related genes, causing tumor cells to gradually lose their epithelial characteristics and acquire more invasive mesenchymal traits. The occurrence of EMT allows tumor cells to better adapt to changes in the surrounding tissue, enhancing their migratory and invasive capabilities, thus promoting tumor progression. At the same time, HIF-1α also plays a crucial regulatory role in ferroptosis in tumor cells. In a hypoxic environment, HIF-1α may affect processes such as iron metabolism and oxidative stress responses, inducing ferroptosis in tumor cells. This article briefly reviews the dual role of HIF-1α in EMT and ferroptosis in tumor cells, helping to gain a deeper understanding of the regulatory pathways of HIF-1α in the development of tumor cells, providing a new perspective for understanding the pathogenesis of tumors. The regulation of HIF-1α may become an important strategy for future tumor therapy.
在肿瘤中，细胞的快速增殖和不完善的血液供应系统导致缺氧，这可以通过缺氧诱导因子-1α（HIF-1α）来调节肿瘤细胞对缺氧环境的适应，并通过多种方式促进肿瘤的发展。最近的研究发现，上皮-间充质转化（EMT）和铁死亡在肿瘤细胞的进展中发挥重要作用。HIF-1α的激活被认为是诱导肿瘤细胞 EMT 的关键因素。当 HIF-1α被激活时，它可以调节 EMT 相关基因，导致肿瘤细胞逐渐失去上皮特征并获得更多侵袭性的间质特征。EMT 的发生使肿瘤细胞能够更好地适应周围组织的变化，增强其迁移和侵袭能力，从而促进肿瘤的进展。同时，HIF-1α在肿瘤细胞的铁死亡中也起着至关重要的调节作用。在缺氧环境中，HIF-1α可能会影响铁代谢和氧化应激反应等过程，诱导肿瘤细胞发生铁死亡。本文简要综述了 HIF-1α在 EMT 和肿瘤细胞铁死亡中的双重作用，有助于更深入地了解 HIF-1α在肿瘤细胞发展中的调控途径，为理解肿瘤的发病机制提供了新的视角。HIF-1α 的调节可能成为未来肿瘤治疗的一个重要策略。
