Atesoglu Halil Ibrahim, Citirik Mehmet, Bengisun Ugur, Yavuzer Kamil
Department of Ophthalmology, Tatvan State Hospital, Bitlis, Turkey.
Department of Ophthalmology, Etlik City Hospital, Ankara, Turkey.
Clin Exp Optom. 2025 Jul;108(5):607-613. doi: 10.1080/08164622.2024.2388129. Epub 2024 Aug 12.
Buerger's disease, being a systemic inflammatory vasculopathy, may present with ocular findings.
This study aims to understand the potential role of optical coherence tomography and angiography findings in evaluating the course of Buerger's disease.
This was a prospective, cross-sectional study that included 25 patients with Buerger's disease (Group 1) and 51 healthy control participants, of whom 27 were smokers (Group 2) and 24 were non-smokers (Group 3). Following a detailed ophthalmic examination, optical coherence tomography and angiography measurements were conducted on participants. The values of macular superficial and deep capillary plexus, peripapillary capillary plexus vessel density measurements were taken into account from optical coherence tomography angiography measurements. Furthermore, measurements were taken for the parameters of the foveal avascular zone, including its area, perimeter and acircularity index. Additionally, the choriocapillaris flow area was assessed between radii of 1 mm, 2 mm, and 3 mm.
In patients with Buerger's disease, the area and perimeter of the foveal avascular zone were higher than in both smoker and non-smoker healthy groups ( < 0.001 for all). The vessel densities in superficial capillary plexus were found to be lower in patients with Buerger's disease compared to both smokers and non-smokers in all regions except the parafovea ( < 0.05 for all). The radial peripapillary capillary plexus vessel densities in the whole retina and peripapillary region were lower than those in the non-smoker group ( < 0.001 and = 0.008). The choriocapillaris flow areas in all three radius were lower in the smoker group than in the non-smoker group (1 mm, = 0.01; 2 mm, = 0.005; 3 mm, = 0.011).
Buerger's disease extends beyond the extremities, affecting vascular density and tissue perfusion in the optic disc and macula, making it a systemic condition. This disease can have ocular involvement without causing serious ocular findings.
血栓闭塞性脉管炎作为一种全身性炎症性血管病，可能出现眼部表现。
本研究旨在了解光学相干断层扫描和血管造影检查结果在评估血栓闭塞性脉管炎病程中的潜在作用。
这是一项前瞻性横断面研究，纳入了25例血栓闭塞性脉管炎患者（第1组）和51名健康对照者，其中27名是吸烟者（第2组），24名是非吸烟者（第3组）。在进行详细的眼科检查后，对参与者进行光学相干断层扫描和血管造影测量。光学相干断层扫描血管造影测量中考虑了黄斑浅层和深层毛细血管丛、视乳头周围毛细血管丛血管密度测量值。此外，还对中心凹无血管区的参数进行了测量，包括其面积、周长和非圆度指数。另外，评估了1毫米、2毫米和3毫米半径范围内的脉络膜毛细血管血流面积。
在血栓闭塞性脉管炎患者中，中心凹无血管区的面积和周长均高于吸烟和非吸烟健康组（均P<0.001）。除黄斑旁区域外，血栓闭塞性脉管炎患者在所有区域的浅层毛细血管丛血管密度均低于吸烟者和非吸烟者（均P<0.05）。整个视网膜和视乳头周围区域的放射状视乳头周围毛细血管丛血管密度低于非吸烟组（分别为P<0.001和P=0.008）。吸烟者组在所有三个半径处的脉络膜毛细血管血流面积均低于非吸烟者组（1毫米，P=0.01；2毫米，P=0.005；3毫米，P=0.011）。
血栓闭塞性脉管炎不仅累及四肢，还会影响视盘和黄斑的血管密度及组织灌注，使其成为一种全身性疾病。这种疾病可累及眼部，但不引起严重的眼部表现。
