Moore A F, Povinelli M A
J Pharm Pharmacol. 1979 Jun;31(6):375-7. doi: 10.1111/j.2042-7158.1979.tb13526.x.
The possible role of degradative enzymes was examined in the specific binding of angiotensin II (AII) to cell membranes. Red blood cell membranes did not bind AII specifically under any of the ambient conditions studied, indicating a lack of AII receptors and no role for the degradative enzymes in specific binding. Rabbit aorta smooth muscle cell membranes bound AII specifically, and this binding had similar characteristics to those previously described for this preparation. It is concluded that specific binding of AII to cell membranes does not involve degradative enzymes, and probably represents binding to the biologically active receptor.
研究了降解酶在血管紧张素II（AII）与细胞膜特异性结合中的可能作用。在所研究的任何环境条件下，红细胞膜都不会特异性结合AII，这表明缺乏AII受体，且降解酶在特异性结合中不起作用。兔主动脉平滑肌细胞膜特异性结合AII，这种结合与该制剂先前描述的结合具有相似的特征。得出的结论是，AII与细胞膜的特异性结合不涉及降解酶，可能代表与生物活性受体的结合。
