波多黎各 2001-2019 年宫颈癌发病率、诊断时分期和死亡率趋势。
Recent cervical cancer incidence, stage at diagnosis, and mortality trends in Puerto Rico, 2001-2019.
机构信息
University of Puerto Rico Comprehensive Cancer Center, P.O. Box 363027, 00936-3027, San Juan, Puerto Rico.
Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
出版信息
BMC Med. 2024 Aug 13;22(1):327. doi: 10.1186/s12916-024-03535-4.
BACKGROUND
Cervical cancer incidence is rising in Puerto Rico (PR). Whether the increase is real or reflective of increased diagnostic scrutiny remains unclear.
METHODS
Using data from the PR Central Cancer Registry for 2001-2019, we estimated trends of hysterectomy-corrected cervical cancer incidence and mortality rates, overall, and by stage at diagnosis and age.
RESULTS
Overall, cervical cancer incidence (per 100,000) increased 1.6%/year (95% CI, -0.5% to 3.8%) from 12.5 to 15.3, with a prominent increase in distant-stage disease (4.5%/year [95% CI, 1.6% to 8.0%]), particularly among screening age eligible (25-64-year-old) women (5.8%/year [95% CI, 2.1% to 10.6%]). Mortality rates in this age-group remained stable during the study period.
CONCLUSIONS
Increased occurrence of distant-stage disease among screening-eligible women is troubling and may reflect a real increase. Future research is needed to elucidate the factors underlying these trends. Improved prevention is also an urgent priority to reverse the rising cervical cancer incidence in PR.
背景
波多黎各（PR）的宫颈癌发病率正在上升。这种增长是真实的，还是反映了诊断审查的增加，目前仍不清楚。
方法
利用 2001 年至 2019 年波多黎各中央癌症登记处的数据，我们估计了子宫切除术校正后的宫颈癌发病率和死亡率的趋势，包括整体趋势以及按诊断时的阶段和年龄划分的趋势。
结果
总体而言，宫颈癌发病率（每 100,000 人）每年增加 1.6%（95%CI，-0.5%至 3.8%），从 12.5 增加到 15.3，远处阶段疾病的显著增加（4.5%/年[95%CI，1.6%至 8.0%]），特别是在筛查年龄（25-64 岁）女性中（5.8%/年[95%CI，2.1%至 10.6%]）。在研究期间，该年龄组的死亡率保持稳定。
结论
在筛查合格的女性中，远处阶段疾病的发生率增加令人担忧，这可能反映了真实的增长。需要进一步的研究来阐明这些趋势背后的因素。改善预防措施也是扭转波多黎各宫颈癌发病率上升的当务之急。
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