Castañeda-Avila M, Torres-Cintrón C R, Cruz-Benítez A, Fuentes-Payán W, Maldonado-Albertorio A, Nieves-Ferrer L, Padró-Juarbe P, Soto-Abreu R, Perez-Ríos N, Ortiz-Ortiz K J, Magno P, Ortiz A P
Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus, San Juan, PR.
Puerto Rico Central Cancer Registry, University of Puerto Rico Comprehensive Cancer Center.
P R Health Sci J. 2019 Sep;38(3):148-155.
To perform an epidemiologic profile of pancreatic cancer (PC) in Puerto Rico (PR) with data gathered from 2001 to 2015.
Using data from the PR Central Cancer Registry we estimated incidence and mortality rates and trends of PC in PR, and performed survival analyses. We also compared the age-standardized incidence and mortality rates of PC in people in PR with those of Hispanics, non-Hispanic whites, and non Hispanic blacks in the United States (US).
From 2011 to 2015, 7.8 per 100,000 persons were diagnosed with PC in PR; higher rates were observed in men than in women (9.2 vs. 6.7 per 100,000, respectively) and in persons 65 years old and older (42.7 per 100,000 persons). For the same period, 6.7 per 100,000 persons died from PC; men and persons 65 years and older had higher mortality rates. Incidence and mortality trends of PC in PR increased from 2001-2015 (annual percent change [APC] = 3.8% and 1.9%, respectively (p<0.05). Lower risk of being diagnosed with and dying from PC was seen in PR than in members of several racial/ethnic groups in the US. The median survival time for PC cases diagnosed in PR during the period of 2008 to 2012 was 5.3 months.
We observed increasing mortality rates and low survival in PC patients in PR. Research on access and response to treatment is needed to elucidate the reasons for the observed results and have a positive impact on PC burden and survival.
利用2001年至2015年收集的数据，对波多黎各（PR）的胰腺癌（PC）进行流行病学分析。
我们使用PR中央癌症登记处的数据，估计了PR地区PC的发病率、死亡率及趋势，并进行了生存分析。我们还比较了PR地区人群与美国（US）西班牙裔、非西班牙裔白人及非西班牙裔黑人的PC年龄标准化发病率和死亡率。
2011年至2015年期间，PR地区每10万人中有7.8人被诊断为PC；男性的发病率高于女性（分别为每10万人9.2例和6.7例），65岁及以上人群的发病率更高（每10万人42.7例）。同期，每10万人中有6.7人死于PC；男性和65岁及以上人群的死亡率更高。2001年至2015年，PR地区PC的发病率和死亡率呈上升趋势（年变化百分比[APC]分别为3.8%和1.9%，p<0.05）。与美国几个种族/族裔群体相比，PR地区被诊断患有PC并死于PC的风险较低。2008年至2012年期间，PR地区诊断出的PC病例的中位生存时间为5.3个月。
我们观察到PR地区PC患者的死亡率上升且生存率较低。需要开展关于治疗可及性和反应的研究，以阐明观察结果的原因，并对PC负担和生存产生积极影响。
