Internal Medicine Department, Rheumatology Division, Health Sciences Center, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.
Medicine School, Rheumatology Division, Universidade do Sul de Santa Catarina (UNISUL), Palhoça, Brazil.
Adv Rheumatol. 2024 Aug 12;64(1):57. doi: 10.1186/s42358-024-00381-z.
Sarcoidosis is a systemic inflammatory disease of unknown origin, which consists of the formation of multiple sterile noncaseating granulomas. Inhaled antigens are believed to initiate disease in prone individuals, considering that almost all patients present pulmonary or mediastinal lymph node disease. Extrapulmonary manifestations are common and diverse: practically any organ system can be affected, and treatment can range from simple watchful waiting to intense immunosuppression. In this article, we review current concepts about sarcoidosis in an overview, focusing on recognition and treatment of its major clinical phenotypes.
结节病是一种病因不明的全身性炎症性疾病，由多个无菌性非干酪样肉芽肿形成。考虑到几乎所有患者均有肺部或纵隔淋巴结疾病，吸入的抗原被认为会在易患个体中引发疾病。肺外表现较为常见且多种多样：几乎任何器官系统都可能受到影响，治疗方法也从单纯的观察等待到强烈的免疫抑制不等。本文将概述结节病的最新概念，重点介绍其主要临床表型的识别和治疗。
