血栓形成的遗传决定因素。
GENETIC DETERMINANTS OF THROMBOSIS.
机构信息
BALTIMORE, MARYLAND.
出版信息
Trans Am Clin Climatol Assoc. 2024;134:230-238.
Abstract
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. VTE is caused by genetic and acquired conditions, but the genetic variants that increase the risk of VTE are not fully characterized. Recent genome-wide association studies (GWAS) have discovered novel genetic loci linked to VTE. Some of these loci have been characterized, uncovering new pathways that regulate VTE. Functional characterization of candidate genes discovered by GWAS may reveal new therapeutic targets to treat and prevent abnormal thrombosis or bleeding.
摘要
静脉血栓栓塞症（VTE）是美国发病率和死亡率的主要原因。VTE 是由遗传和获得性因素引起的，但增加 VTE 风险的遗传变异尚未完全确定。最近的全基因组关联研究（GWAS）发现了与 VTE 相关的新的遗传位点。其中一些位点已经得到了描述，揭示了调节 VTE 的新途径。通过 GWAS 发现的候选基因的功能特征可能会揭示新的治疗靶点，以治疗和预防异常血栓形成或出血。
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