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超越生殖:揭示性激素对心脏代谢健康的影响

Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health.

作者信息

Xega Viktoria, Liu Jun-Li

机构信息

MeDiC Program, The Research Institute of McGill University Health Centre, Montreal, Canada.

Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Canada.

出版信息

Med Rev (2021). 2024 May 23;4(4):284-300. doi: 10.1515/mr-2024-0012. eCollection 2024 Aug.

Abstract

This review thoroughly explores the multifaceted roles of sexual hormones, emphasizing their impact beyond reproductive functions and underscoring their significant influence on cardiometabolic regulation. It analyzes the broader physiological implications of estrogen, testosterone, and progesterone, highlighting their effects on metabolic syndrome, lipid metabolism, glucose homeostasis, and cardiovascular health. Drawing from diverse molecular, clinical, and therapeutic studies, the paper delves into the intricate interplay between these hormones and cardiometabolic processes. By presenting a comprehensive analysis that goes beyond traditional perspectives, and recognizing sexual hormones as more than reproductive agents, the review sheds light on their broader significance in health and disease management, advocating for holistic and personalized medical approaches.

摘要

本综述全面探讨了性激素的多方面作用,强调了它们在生殖功能之外的影响,并着重指出了它们对心脏代谢调节的重大影响。它分析了雌激素、睾酮和孕酮更广泛的生理意义,突出了它们对代谢综合征、脂质代谢、葡萄糖稳态和心血管健康的影响。本文借鉴了各种分子、临床和治疗研究,深入探讨了这些激素与心脏代谢过程之间复杂的相互作用。通过提供超越传统观点的全面分析,并认识到性激素不仅仅是生殖因子,该综述揭示了它们在健康和疾病管理中的更广泛意义,倡导采用整体和个性化的医疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5587/11317208/f3f7f546b545/j_mr-2024-0012_fig_001.jpg

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