Medical Oncology Department of Thoracic Cancer 1, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China.
Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China.
Front Immunol. 2024 Jul 29;15:1418580. doi: 10.3389/fimmu.2024.1418580. eCollection 2024.
Brain metastatic cancer poses a significant clinical challenge, with limited treatment options and poor prognosis for patients. In recent years, immunotherapy has emerged as a promising strategy for addressing brain metastases, offering distinct advantages over conventional treatments. This review explores the evolving landscape of tumor immunotherapy in the context of brain metastatic cancer, focusing on the intricate interplay between the tumor microenvironment (TME) and immunotherapeutic approaches. By elucidating the complex interactions within the TME, including the role of immune cells, cytokines, and extracellular matrix components, this review highlights the potential of immunotherapy to reshape the treatment paradigm for brain metastases. Leveraging immune checkpoint inhibitors, cellular immunotherapies, and personalized treatment strategies, immunotherapy holds promise in overcoming the challenges posed by the blood-brain barrier and immunosuppressive microenvironment of brain metastases. Through a comprehensive analysis of current research findings and future directions, this review underscores the transformative impact of immunotherapy on the management of brain metastatic cancer, offering new insights and opportunities for personalized and precise therapeutic interventions.
脑转移癌是一个重大的临床挑战，患者的治疗选择有限，预后较差。近年来，免疫疗法已成为治疗脑转移瘤的一种很有前途的策略，与传统治疗方法相比具有明显的优势。本综述探讨了肿瘤免疫疗法在脑转移癌中的发展现状，重点研究了肿瘤微环境（TME）与免疫治疗方法之间的复杂相互作用。通过阐明 TME 中的复杂相互作用，包括免疫细胞、细胞因子和细胞外基质成分的作用，本综述强调了免疫疗法重塑脑转移治疗模式的潜力。免疫疗法利用免疫检查点抑制剂、细胞免疫疗法和个性化治疗策略，有望克服血脑屏障和脑转移瘤免疫抑制微环境带来的挑战。通过对当前研究结果和未来方向的全面分析，本综述强调了免疫疗法对脑转移癌管理的变革性影响，为个性化和精准治疗干预提供了新的见解和机会。
