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Myocardial Krüppel-Like Factor 5 Abundance Holds Prognostic Value for Myocardial Recovery of Patients With Heart Failure Following Mechanical Unloading and Circulatory Support.

作者信息

Siokatas Georgios, Hamouche Rana, Maneta Eleni, Selzman Craig, Hatzistergos Konstantinos E, Drakos Stavros G, Drosatos Konstantinos

机构信息

Metabolic Biology Laboratory, Cardiovascular Center, Department of Pharmacology and Systems Physiology University of Cincinnati College of Medicine Cincinnati OH USA.

Department of Genetics, Development and Molecular Biology, School of Biology, Faculty of Sciences Aristotle University of Thessaloniki Thessaloniki Greece.

出版信息

J Am Heart Assoc. 2024 Aug 20;13(16):e035661. doi: 10.1161/JAHA.124.035661. Epub 2024 Aug 13.

DOI:10.1161/JAHA.124.035661
PMID:39136355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11963911/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7e/11963911/ab131fda8043/JAH3-13-e035661-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7e/11963911/ab131fda8043/JAH3-13-e035661-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7e/11963911/ab131fda8043/JAH3-13-e035661-g001.jpg

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Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support.明确的转录组学和蛋白质组学特征可鉴定出在机械卸载和循环支持下具有潜在心肌恢复能力的心力衰竭患者。
Circulation. 2023 Jan 31;147(5):409-424. doi: 10.1161/CIRCULATIONAHA.121.056600. Epub 2022 Nov 30.
2
Krüppel-like factor (KLF)5: An emerging foe of cardiovascular health.Krüppel 样因子 5(KLF5):心血管健康的新兴敌人。
J Mol Cell Cardiol. 2022 Feb;163:56-66. doi: 10.1016/j.yjmcc.2021.10.002. Epub 2021 Oct 13.
3
Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy.
心肌细胞 Krüppel 样因子 5 促进从头合成神经酰胺并有助于缺血性心肌病的离心性重构。
Circulation. 2021 Mar 16;143(11):1139-1156. doi: 10.1161/CIRCULATIONAHA.120.047420. Epub 2021 Jan 12.
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Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure]): Medium-Term and Primary End Point Results.采用左心室辅助装置的心肌恢复前瞻性多中心研究(RESTAGE-HF[心力衰竭 D 期缓解]):中期和主要终点结果。
Circulation. 2020 Nov 24;142(21):2016-2028. doi: 10.1161/CIRCULATIONAHA.120.046415. Epub 2020 Oct 26.
5
Myocardial Recovery in Patients Receiving Contemporary Left Ventricular Assist Devices: Results From the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS).接受当代左心室辅助装置患者的心肌恢复:来自机构间机械辅助循环支持注册研究(INTERMACS)的结果
Circ Heart Fail. 2016 Jul;9(7). doi: 10.1161/CIRCHEARTFAILURE.116.003157.