sEH activity is associated with mortality in patients with ARDS: a retrospective cohort study.

We hypothesized plasma sEH activity correlates with mortality in acute respiratory distress syndrome (ARDS) patients. Adult patients diagnosed with ARDS enrolled between 2017 and 2019 were included in this study. A total of 337 adult patients met our inclusion criteria. Among them, 107 patients died within 28 days. The plasma sEH activity was higher in nonsurvivors relative to survivors. And a receiver operating characteristic curve with the area under the curve of 0.81 (95% confidence interval: 0.74-0.89) for the prediction of 28-day mortality was obtained. Its sensitivity and specificity were 72.5% and 74.6%, respectively. Elevated plasma sEH activity is associated with higher 28-day mortality in adult patients with ARDS.