Department of Respiratory Medicine, Cangzhou People's Hospital, Cangzhou 061000, China.
Biomark Med. 2024;18(10-12):513-521. doi: 10.1080/17520363.2024.2347199. Epub 2024 Aug 13.
This study intended to investigate the ability of blood to estimate acute exacerbation risk in elderly chronic obstructive pulmonary disease (COPD) patients. Blood was detected in 176 elderly COPD patients (aged more than 60 years). was elevated in patients with COPD acute exacerbation versus patients with stable COPD ( < 0.001). In patients with COPD acute exacerbation, was negatively related to forced expiratory volume in 1 s (FEV)/forced vital capacity (FVC) ( = 0.024) and FEV% predicted ( = 0.002), but positively linked with global initiative for chronic obstructive lung disease stage ( = 0.005). Blood reflects increased acute exacerbation risk and inflammation in elderly COPD patients.
本研究旨在探讨血液在评估老年慢性阻塞性肺疾病（COPD）患者急性加重风险中的能力。检测了 176 例老年 COPD 患者（年龄>60 岁）的血液。与稳定期 COPD 患者相比，COPD 急性加重患者的 升高（<0.001）。在 COPD 急性加重患者中，与 1 秒用力呼气量（FEV）/用力肺活量（FVC）（=0.024）和 FEV%预计值（=0.002）呈负相关，但与慢性阻塞性肺疾病全球倡议分期（=0.005）呈正相关。血液反映了老年 COPD 患者急性加重风险增加和炎症反应。
