Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Int J Mol Sci. 2023 May 13;24(10):8725. doi: 10.3390/ijms24108725.
Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD) and atherosclerotic cardiovascular disease (ASCVD). These diseases share common pathogenesis and significantly influence each other's clinical presentation and prognosis. There is increasing evidence that the mechanisms underlying the comorbidity of COPD and ASCVD are complex and multifactorial. Smoking-induced systemic inflammation, impaired endothelial function and oxidative stress may contribute to the development and progression of both diseases. The components present in tobacco smoke can have adverse effects on various cellular functions, including macrophages and endothelial cells. Smoking may also affect the innate immune system, impair apoptosis, and promote oxidative stress in the respiratory and vascular systems. The purpose of this review is to discuss the importance of smoking in the mechanisms underlying the comorbid course of COPD and ASCVD.
吸烟是慢性阻塞性肺疾病（COPD）和动脉粥样硬化性心血管疾病（ASCVD）的主要原因。这些疾病具有共同的发病机制，并显著影响彼此的临床表现和预后。越来越多的证据表明，COPD 和 ASCVD 合并症的机制复杂且多因素。吸烟引起的全身炎症、内皮功能障碍和氧化应激可能导致这两种疾病的发生和发展。烟草烟雾中的成分会对包括巨噬细胞和内皮细胞在内的各种细胞功能产生不良影响。吸烟还可能影响先天免疫系统，损害细胞凋亡，并促进呼吸系统和血管系统的氧化应激。本文旨在讨论吸烟在 COPD 和 ASCVD 合并病程的机制中的重要性。
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