Department of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 Changlexi Road, Xi'an, 710032, Shaanxi, China.
Arch Dermatol Res. 2024 Aug 13;316(8):519. doi: 10.1007/s00403-024-03265-w.
Vitiligo is an autoimmune disorder characterized by epidermal melanocyte damage, with the typical clinical manifestation of white patches of skin. Keratinocytes, which work in concert with melanocytes to maintain the structural and functional integrity of the skin, are implicated in the progression of vitiligo. Recent studies have reported abnormal keratinocyte proliferation and epidermal thickening in some patients with vitiligo; however, the relationship between these changes and the clinical characteristics of vitiligo remains unclear. We assessed the changes in epidermal thickness in patients with vitiligo and their correlation with clinical characteristics. Compared to the non-lesional skins, the stratum corneum, viable epidermis, and full epidermis in the lesional skins were all significantly thicker. The thickness of the stratum corneum in the head, neck, and trunk was greatly lower than that in the extremities. The thickness of the stratum corneum in the sun-exposed area was higher than that in the sun-protected area, whereas the thickness of the viable epidermis decreased. In conclusion, our study found that the epidermis in the lesional skins of patients with vitiligo was significantly thickened, especially in the sun-exposed areas and extremities.
白癜风是一种自身免疫性疾病，其特征是表皮黑素细胞损伤，典型的临床表现为皮肤白斑。角朊细胞与黑素细胞协同作用，维持皮肤的结构和功能完整性，与白癜风的进展有关。最近的研究报告称，一些白癜风患者的角朊细胞增殖和表皮增厚异常；然而，这些变化与白癜风的临床特征之间的关系尚不清楚。我们评估了白癜风患者的表皮厚度变化及其与临床特征的相关性。与非皮损皮肤相比，皮损皮肤的角质层、有活力的表皮和全表皮均显著增厚。头部、颈部和躯干的角质层厚度明显低于四肢。暴露部位的角质层厚度高于非暴露部位，而有活力的表皮厚度则减少。总之，我们的研究发现，白癜风患者皮损皮肤的表皮明显增厚，特别是在暴露部位和四肢。
