外泌体在突触处传递的不是信息而是“垃圾”。
EVs move messes, not messages, at the synapse.
机构信息
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
出版信息
J Cell Biol. 2024 Sep 2;223(9). doi: 10.1083/jcb.202408028. Epub 2024 Aug 13.
Abstract
Extracellular vesicles are known for intercellular signaling roles but can also serve to simply dispose of unwanted cargoes. In this issue, Bostelman and Broihier discuss new work from Rodal and colleagues (https://doi.org/10.1083/jcb.202405025) that refutes prior work by showing that extracellular vesicles at Drosophila neuromuscular junctions are not required for signaling and instead likely serve a proteostasis role.
摘要
细胞外囊泡以细胞间信号传递作用而闻名，但也可以简单地处理不需要的货物。在本期杂志中，Bostelman 和 Broihier 讨论了 Rodal 及其同事的新工作（https://doi.org/10.1083/jcb.202405025），该工作反驳了先前的工作，表明果蝇神经肌肉接头处的细胞外囊泡不需要用于信号传递，而是可能起保护蛋白质稳态的作用。
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本文引用的文献
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