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由β2-肾上腺素能神经生长因子前馈环介导的神经-间充质相互作用促进结直肠癌进展。

Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression.

作者信息

Kobayashi Hiroki, Iida Tadashi, Ochiai Yosuke, Malagola Ermanno, Zhi Xiaofei, White Ruth A, Qian Jin, Wu Feijing, Waterbury Quin T, Tu Ruhong, Zheng Biyun, LaBella Jonathan S, Zamechek Leah B, Ogura Atsushi, Woods Susan L, Worthley Daniel L, Enomoto Atsushi, Wang Timothy C

机构信息

Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center Columbia University Medical Center, New York, New York.

Columbia University Digestive and Liver Disease Research Center, New York, New York.

出版信息

Cancer Discov. 2025 Jan 13;15(1):202-226. doi: 10.1158/2159-8290.CD-24-0287.

DOI:10.1158/2159-8290.CD-24-0287
PMID:39137067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11729495/
Abstract

Our work demonstrates that the bidirectional interplay between sympathetic nerves and NGF-expressing CAFs drives colorectal tumorigenesis. This study also offers novel mechanistic insights into catecholamine action in colorectal cancer. Inhibiting the neuro-mesenchymal interaction by TRK blockade could be a potential strategy for treating colorectal cancer.

摘要

我们的研究表明，交感神经与表达神经生长因子（NGF）的癌相关成纤维细胞（CAFs）之间的双向相互作用驱动了结直肠癌的发生。这项研究还为儿茶酚胺在结直肠癌中的作用提供了新的机制性见解。通过TRK阻断抑制神经-间充质相互作用可能是治疗结直肠癌的一种潜在策略。

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本文引用的文献

1
Protocol for the isolation of the mouse sympathetic splanchnic-celiac-superior mesenteric ganglion complex.用于分离小鼠交感肠系膜-腹腔-肠系膜上神经节复合体的方案。
STAR Protoc. 2024 Jun 21;5(2):103036. doi: 10.1016/j.xpro.2024.103036. Epub 2024 Apr 26.
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Leptin receptor cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor.瘦素受体细胞通过合成神经生长因子促进骨髓神经支配和再生。
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Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α.
神经生长因子：外科医生和肿瘤学家能从一种神经学和心理学生物标志物中学到什么？
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Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1.Netrin-1通过NEO1促进胰腺肿瘤发生和神经支配。
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Tumor-Associated Sympathetic Nerves Promote the Progression of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma.肿瘤相关交感神经促进爱泼斯坦-巴尔病毒阳性弥漫性大B细胞淋巴瘤的进展。
Adv Sci (Weinh). 2025 Sep;12(33):e13580. doi: 10.1002/advs.202413580. Epub 2025 Jun 9.
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Cancer and neurotransmitter receptors.癌症与神经递质受体
Chin Med J (Engl). 2025 Jul 5;138(13):1540-1558. doi: 10.1097/CM9.0000000000003656. Epub 2025 May 30.
7
Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA.心理应激诱导的ALKBH5缺陷通过细胞外囊泡RNA转移促进肿瘤神经支配和胰腺癌。
Nat Cell Biol. 2025 May 26. doi: 10.1038/s41556-025-01667-0.
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