由β2-肾上腺素能神经生长因子前馈环介导的神经-间充质相互作用促进结直肠癌进展。
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression.
作者信息
Kobayashi Hiroki, Iida Tadashi, Ochiai Yosuke, Malagola Ermanno, Zhi Xiaofei, White Ruth A, Qian Jin, Wu Feijing, Waterbury Quin T, Tu Ruhong, Zheng Biyun, LaBella Jonathan S, Zamechek Leah B, Ogura Atsushi, Woods Susan L, Worthley Daniel L, Enomoto Atsushi, Wang Timothy C
机构信息
Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center Columbia University Medical Center, New York, New York.
Columbia University Digestive and Liver Disease Research Center, New York, New York.
出版信息
Cancer Discov. 2025 Jan 13;15(1):202-226. doi: 10.1158/2159-8290.CD-24-0287.
Abstract
Our work demonstrates that the bidirectional interplay between sympathetic nerves and NGF-expressing CAFs drives colorectal tumorigenesis. This study also offers novel mechanistic insights into catecholamine action in colorectal cancer. Inhibiting the neuro-mesenchymal interaction by TRK blockade could be a potential strategy for treating colorectal cancer.
摘要
我们的研究表明，交感神经与表达神经生长因子（NGF）的癌相关成纤维细胞（CAFs）之间的双向相互作用驱动了结直肠癌的发生。这项研究还为儿茶酚胺在结直肠癌中的作用提供了新的机制性见解。通过TRK阻断抑制神经-间充质相互作用可能是治疗结直肠癌的一种潜在策略。
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