Tang Zhuojun, Wei Yiying, Liang Yanqing, Zhu Xuexian, Tang Junjie, Sun Yulin, Zhuang Qingyuan
The Second Clinical Medical School, Nanjing Medical University.
The Forth Clinical Medical School, Nanjing Medical University.
Eur J Cancer Prev. 2025 Mar 1;34(2):130-139. doi: 10.1097/CEJ.0000000000000909. Epub 2024 Jul 23.
Breast cancer, the most prevalent tumor in women globally, significantly impacts young women, compromising their daily lives and overall well-being. Breast cancer represents a significant public health concern due to its extensive physical and psychological consequences.
Data from the Global Burden of Disease (GBD) were used to assess the global, regional, and national burden of breast cancer in young women aged 20-39 from 1990 to 2021. This analysis focused on trends measured by the estimated annual percentage change (EAPC) and explored the socioeconomic impacts via the sociodemographic index (SDI).
During 1990-2021, the incidence and prevalence of breast cancer among young women increased globally, with annual rates of 0.82 and 0.87%, respectively. The mortality rate and disability-adjusted life years (DALYs) also rose annually by -0.12% and -0.05, respectively. A significant burden shift was observed towards regions with lower SDI, with diet high in red meat, alcohol use, and high fasting plasma glucose identified as prominent risk factors, particularly in lower SDI regions.
Our findings underscore breast cancer in young women as an escalating global health challenge, with the burden increasingly shifting towards lower socioeconomic areas. This underscores the necessity for targeted prevention and control strategies for breast cancer, focusing on reducing the identified risk factors and ensuring equitable health resource distribution.
乳腺癌是全球女性中最常见的肿瘤，对年轻女性有重大影响，损害她们的日常生活和整体健康。由于其广泛的身体和心理后果，乳腺癌是一个重大的公共卫生问题。
利用全球疾病负担（GBD）的数据评估1990年至2021年20至39岁年轻女性乳腺癌的全球、区域和国家负担。该分析侧重于以估计年百分比变化（EAPC）衡量的趋势，并通过社会人口指数（SDI）探讨社会经济影响。
在1990 - 2021年期间，全球年轻女性乳腺癌的发病率和患病率均有所上升，年增长率分别为0.82%和0.87%。死亡率和伤残调整生命年（DALYs）也分别以每年-0.12%和-0.05%的速度上升。观察到负担显著向SDI较低的地区转移，红肉含量高的饮食、饮酒和高空腹血糖被确定为突出的风险因素，尤其是在SDI较低的地区。
我们的研究结果强调年轻女性乳腺癌是一个不断升级的全球健康挑战，负担日益向社会经济较低地区转移。这凸显了针对乳腺癌制定有针对性的预防和控制策略的必要性，重点是减少已确定的风险因素并确保公平的卫生资源分配。
