Varela-Izquierdo Víctor, Mustieles-Marín Irene, Fazzini Pier-Francesco, Mencía Gabriel, Guelen Simon, Rachet Rabih, Chaudret Bruno
Laboratoire de Physique et Chimie des Nano-Objets, Université de Toulouse, LPCNO, INSA, UPS, CNRS-UMR5215, 135 Avenue de Rangueil, 31077, Toulouse, France.
CEMES-CNRS, Université de Toulouse, CNRS, 29 rue Jeanne Marvig, 31055, Toulouse, France.
Angew Chem Int Ed Engl. 2024 Dec 9;63(50):e202412421. doi: 10.1002/anie.202412421. Epub 2024 Oct 29.
The synthesis of tertiary amines from alcohols (i.e. heptanol, dodecanol, cyclohexanol, benzylalcohol) and secondary amines (MeNH (DMA), PrNH, BuNH) has been achieved in one step using trimetallic nanoparticles (NPs) displaying a magnetic core (CoNi and FeNi) and a Cu shell as both catalysts and heating agent in the presence of an alternating magnetic field. This methodology limits the redistribution reactions occurring on amines at high temperature leading to both much higher conversion and selectivity in the absence of solvent than usually observed using conventional heating. Moreover, CoNi@Cu NPs were found moisture resistant, thereby allowing for performing the reaction with commercial DMA in water (40 % wt) with again high conversion and selectivity.
使用具有磁性核（CoNi和FeNi）和Cu壳的三金属纳米颗粒（NPs）作为催化剂和加热剂，在交变磁场存在下，已实现了由醇（即庚醇、十二烷醇、环己醇、苯甲醇）和仲胺（MeNH（DMA）、PrNH、BuNH）一步合成叔胺。该方法限制了高温下胺上发生的再分配反应，从而在无溶剂的情况下比通常使用传统加热时具有更高的转化率和选择性。此外，发现CoNi@Cu NPs具有防潮性，因此能够在水（40 % wt）中与市售DMA进行反应，同样具有高转化率和选择性。
