Ernst E
Int Angiol. 1985 Jul-Sep;4(3):373-7.
Despite considerable uncontrolled clinical data implying a beneficial effect of defibrinogenation in peripheral vascular disease, this is not supported by double blind placebo controlled trials. A hypothetical explanation for this discrepancy is developed from experimental studies suggesting that in the absence of adequate shear forces defibrinogenation might induce occlusion of the impaired microcirculation and therefore can lead to an aggravation of tissue hypoxia.
尽管大量非对照临床数据表明去纤维蛋白原疗法对外周血管疾病有有益作用，但双盲安慰剂对照试验并未证实这一点。基于实验研究提出了一个对这种差异的假设性解释，即提示在缺乏足够剪切力的情况下，去纤维蛋白原疗法可能会导致受损微循环的阻塞，从而加重组织缺氧。
