Lee M H, Zarestsky H H, Ernst M, Dworkin B, Jonas R
J Med. 1985;16(4):417-28.
We examined the relative analgesic potency of aspirin and placebo in a within-subject-repeated-measure experiment using a precision tooth pulp stimulation technique with long-term stability (r = 0.93) for more than two months between measures. The attenuation of pain perception was evaluated using a standardized magnitude estimation procedure and constructing an individual psychophysical function for each trial. The data were fit equally well by either a straight line (Y = mX + b) or a power function (Y = mXa + b). Using the line fit and distribution insensitive conservative statistical tests, the effect of each treatment was compared to baseline and the treatments were compared to each other. In randomized, double-blind trials we found reliable effects of both aspirin (p less than 0.001) and placebo (p less than 0.001) but no difference (p = 0.08) between these two treatments. However, on an individual basis, 12 of 17 subjects displayed a larger analgesic response to aspirin than to placebo (p less than 0.05).
我们在一项受试者内重复测量实验中，使用一种具有长期稳定性（测量之间超过两个月，r = 0.93）的精确牙髓刺激技术，检验了阿司匹林和安慰剂的相对镇痛效力。使用标准化的量级估计程序并为每个试验构建个体心理物理函数，来评估疼痛感知的减弱情况。数据用直线（Y = mX + b）或幂函数（Y = mXa + b）拟合效果相同。使用直线拟合和分布不敏感的保守统计检验，将每种治疗的效果与基线进行比较，并将两种治疗相互比较。在随机双盲试验中，我们发现阿司匹林（p < 0.001）和安慰剂（p < 0.001）均有可靠效果，但这两种治疗之间无差异（p = 0.08）。然而，在个体层面上，17名受试者中有12名对阿司匹林的镇痛反应大于对安慰剂的反应（p < 0.05）。
