Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjadjaran, Indonesia.
Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia.
J Wound Care. 2024 Aug 2;33(8):570-576. doi: 10.12968/jowc.2022.0020.
Acute laceration wound (ALW) is one of the most common injuries in Indonesia with potential significant morbidities. In rural areas, povidone-iodine and honey are commonly used as wound dressings. This study aimed to identify the effectiveness of honey compared to paraffin gauze and the commonly used povidone-iodine in improving ALW healing time.
This study was a single-blind, pilot randomised controlled trial (RCT) with three intervention groups (honey, povidone-iodine, and paraffin). The outcomes were wound healing time, slow healing, secondary healing, signs of infection, wound dehiscence, oedema, maceration, necrosis, exudate and cost.
A total of 35 patients (male to female ratio: 4:1), with a mean age of 22.5 (range: 6-47) years, were included and randomised to treatment groups using predetermined randomisation according to wound location and wound dressing selection: honey group, n=12; povidone-iodine group, n=11; paraffin group, n=12 with one patient lost to follow-up. All groups achieved timely healing, with a mean healing time of 9.45±5.31 days and 11.09±5.14 days for the povidone-iodine and paraffin groups, respectively, and a median healing time of 10 (3-19) days for the honey group (p>0.05). More wounds in the honey group achieved healing in ≤10 days compared with the other groups. Both povidone-iodine and honey groups had fewer adverse events, with the latter having the lowest cost.
In this study, honey was clinically effective in accelerating healing time with a lower cost compared to paraffin, and was comparable to povidone-iodine. Future RCTs with a larger sample size should be pursued to determine honey's role in ALW treatment.
急性撕裂伤（ALW）是印度尼西亚最常见的创伤之一，具有潜在的严重发病率。在农村地区，聚维酮碘和蜂蜜通常被用作伤口敷料。本研究旨在确定与石蜡纱布和常用的聚维酮碘相比，蜂蜜在缩短 ALW 愈合时间方面的效果。
这是一项单盲、前瞻性随机对照试验（RCT），有三个干预组（蜂蜜组、聚维酮碘组和石蜡组）。结果为伤口愈合时间、愈合缓慢、二期愈合、感染迹象、伤口裂开、水肿、浸渍、坏死、渗出物和成本。
共纳入 35 例患者（男女比例为 4:1），平均年龄为 22.5 岁（范围：6-47 岁），根据伤口位置和伤口敷料选择，采用预先确定的随机分组方法将患者随机分为治疗组：蜂蜜组 12 例；聚维酮碘组 11 例；石蜡组 12 例，其中 1 例失访。所有组均及时愈合，聚维酮碘组和石蜡组的平均愈合时间分别为 9.45±5.31 天和 11.09±5.14 天，蜂蜜组的中位愈合时间为 10（3-19）天（p>0.05）。与其他组相比，蜂蜜组更多的伤口在 10 天内愈合。聚维酮碘组和蜂蜜组的不良事件较少，后者的成本最低。
在这项研究中，与石蜡相比，蜂蜜在加速愈合时间方面具有临床效果，且成本更低，与聚维酮碘相当。应进行更大样本量的 RCT 以确定蜂蜜在 ALW 治疗中的作用。
