Offen W W, Gruber C M
J Med. 1985;16(4):439-52.
This paper evaluates the dose-response relationship of several doses of fenoprofen calcium, between 12.5 and 300 mg, and their relationship to 60 mg of codeine sulfate and placebo. Three separate parallel studies are included in this evaluation, including a total of 867 patients. The types of pain were cesarean section, episiotomy wound, uterine cramping, and general surgery. This paper shows that a significant increasing relationship exists between efficacy and dose of fenoprofen, suggesting that relatively larger doses of fenoprofen will achieve greater amounts of efficacy.
本文评估了12.5至300毫克几种剂量的非诺洛芬钙之间的剂量反应关系，以及它们与60毫克硫酸可待因和安慰剂的关系。该评估包括三项独立的平行研究，共有867名患者。疼痛类型包括剖宫产、会阴切开术伤口、子宫绞痛和普通外科手术。本文表明，非诺洛芬的疗效与剂量之间存在显著的递增关系，这表明相对较大剂量的非诺洛芬将产生更大的疗效。
