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1
Provider Factors Likely to Impact Access and Uptake of Long-Acting Injectable Cabotegravir for Transgender Women in the United States: Results of a Qualitative Study.影响美国跨性别女性使用长效注射用卡替拉韦的可及性和接受度的提供者因素:定性研究结果。
J Assoc Nurses AIDS Care. 2024;35(5):437-449. doi: 10.1097/JNC.0000000000000488. Epub 2024 Aug 13.
2
Strategies for implementing long-acting cabotegravir for PrEP in US clinics serving Black women: interim healthcare provider findings from the EBONI study.在美国为黑人女性服务的诊所中实施长效卡博特韦用于暴露前预防的策略:EBONI研究中医疗保健提供者的中期结果
J Int AIDS Soc. 2025 Jul;28 Suppl 2(Suppl 2):e26497. doi: 10.1002/jia2.26497.
3
Willingness to Use Long-Acting Injectable Cabotegravir and Associated Factors Among Men Who Have Sex with Men in Guangxi, China.中国广西男男性行为者使用长效注射型卡替拉韦的意愿及其相关因素。
Arch Sex Behav. 2024 Jul;53(7):2795-2806. doi: 10.1007/s10508-024-02886-6. Epub 2024 Jun 7.
4
Perspectives Among Health Care Providers and People with HIV on the Implementation of Long-Acting Injectable Cabotegravir/Rilpivirine for Antiretroviral Therapy in Florida.佛罗里达州卫生保健提供者和 HIV 感染者对长效注射用卡替拉韦/利匹韦林用于抗逆转录病毒治疗实施情况的看法。
AIDS Patient Care STDS. 2024 Jun;38(6):275-285. doi: 10.1089/apc.2024.0067. Epub 2024 Apr 30.
5
Feasibility and acceptability of persons on long-acting cabotegravir for HIV prevention in the SEARCH Dynamic Choice HIV Prevention trial extension in rural Kenya and Uganda: a longitudinal cohort study.在肯尼亚农村和乌干达开展的SEARCH动态选择HIV预防试验扩展研究中,长效卡博特韦用于HIV预防的可行性及可接受性:一项纵向队列研究
J Int AIDS Soc. 2025 Jul;28 Suppl 2(Suppl 2):e26465. doi: 10.1002/jia2.26465.
6
Exploring perceptions and preferences for PrEP choice and of an mHealth intervention: insights from the ImPrEP CAB-Brasil study.探索对暴露前预防(PrEP)选择及移动健康干预措施的认知和偏好:来自巴西ImPrEP社区咨询委员会(CAB)研究的见解
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PrEP preferences and early acceptability of injectable cabotegravir among pregnant and lactating people in Cape Town, South Africa: findings from the PrEPared to Choose study.南非开普敦孕妇和哺乳期妇女对注射用卡博特韦的暴露前预防偏好及早期可接受性:“准备好选择”研究的结果
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Cost-effective pricing of long-acting injectable HIV pre-exposure prophylaxis for adolescent girls and young women in South Africa: a model-based analysis.南非针对青春期女孩和年轻女性的长效注射用艾滋病毒暴露前预防药物的成本效益定价:基于模型的分析
Lancet Glob Health. 2025 May 26. doi: 10.1016/S2214-109X(25)00119-6.
9
Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women.卡博特韦用于预防顺性别男性和跨性别女性中的 HIV。
N Engl J Med. 2021 Aug 12;385(7):595-608. doi: 10.1056/NEJMoa2101016.
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Need for informed providers: exploring LA-PrEP access in focus groups with PrEP-indicated communities in Baltimore, Maryland.知情提供者的需求:在马里兰州巴尔的摩的有接受 PrEP 指征的社区的焦点小组中探索 LA-PrEP 的可及性。
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本文引用的文献

1
HIV incidence and mortality in transgender women in the eastern and southern USA: a multisite cohort study.美国东南部和东部跨性别女性中的 HIV 发病率和死亡率:一项多地点队列研究。
Lancet HIV. 2023 May;10(5):e308-e319. doi: 10.1016/S2352-3018(23)00008-5. Epub 2023 Feb 28.
2
Prevention-effective adherence trajectories among transgender women indicated for PrEP in the United States: a prospective cohort study.美国符合接受 PrEP 治疗的跨性别女性中的预防有效坚持轨迹:一项前瞻性队列研究。
Ann Epidemiol. 2022 Jun;70:23-31. doi: 10.1016/j.annepidem.2022.03.016. Epub 2022 Apr 6.
3
Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women.卡博特韦用于预防顺性别男性和跨性别女性中的 HIV。
N Engl J Med. 2021 Aug 12;385(7):595-608. doi: 10.1056/NEJMoa2101016.
4
Transgender Women's Barriers, Facilitators, and Preferences on Tailored Injection Delivery Strategies to Administer Long-Acting Injectable Cabotegravir (CAB-LA) for HIV Pre-exposure Prophylaxis (PrEP).跨性别女性在接受长效注射型卡替拉韦(CAB-LA)用于 HIV 暴露前预防(PrEP)时,对定制注射递药策略的障碍、促进因素和偏好。
AIDS Behav. 2021 Dec;25(12):4180-4192. doi: 10.1007/s10461-021-03357-y. Epub 2021 Jul 3.
5
Characterization of Human Immunodeficiency Virus (HIV) Infection in Cisgender Men and Transgender Women Who Have Sex With Men Receiving Injectable Cabotegravir for HIV Prevention: HPTN 083.接受注射用卡博特韦预防艾滋病毒的男同性恋和顺性别男性及跨性别女性中人类免疫缺陷病毒(HIV)感染的特征:HPTN 083研究
J Infect Dis. 2021 Nov 16;224(9):1581-1592. doi: 10.1093/infdis/jiab152.
6
Assessing the Role of Long-Acting Cabotegravir Preexposure Prophylaxis of Human Immunodeficiency Virus: Opportunities and Aspirations.评估长效卡博特韦暴露前预防人类免疫缺陷病毒的作用:机遇与展望
J Infect Dis. 2021 Jan 4;223(1):1-3. doi: 10.1093/infdis/jiaa555.
7
Understanding the Acceptability of Subdermal Implants as a Possible New HIV Prevention Method: Multi-Stage Mixed Methods Study.了解皮下植入作为一种可能的新型艾滋病毒预防方法的可接受性:多阶段混合方法研究。
J Med Internet Res. 2020 Jul 27;22(7):e16904. doi: 10.2196/16904.
8
Health Care Provider Barriers to HIV Pre-Exposure Prophylaxis in the United States: A Systematic Review.美国卫生保健提供者在 HIV 暴露前预防措施方面面临的障碍:系统评价。
AIDS Patient Care STDS. 2020 Mar;34(3):111-123. doi: 10.1089/apc.2019.0189. Epub 2020 Feb 28.
9
Preferences for implementation of HIV pre-exposure prophylaxis (PrEP): Results from a survey of primary care providers.艾滋病病毒暴露前预防(PrEP)实施偏好:基层医疗服务提供者的调查结果
Prev Med Rep. 2019 Oct 21;17:101012. doi: 10.1016/j.pmedr.2019.101012. eCollection 2020 Mar.
10
Transgender Women's Concerns and Preferences on Potential Future Long-Acting Biomedical HIV Prevention Strategies: The Case of Injections and Implanted Medication Delivery Devices (IMDDs).跨性别女性对潜在未来长效生物医学 HIV 预防策略的关注和偏好:以注射和植入式药物输送装置(IMDDs)为例。
AIDS Behav. 2020 May;24(5):1452-1462. doi: 10.1007/s10461-019-02703-5.

影响美国跨性别女性使用长效注射用卡替拉韦的可及性和接受度的提供者因素:定性研究结果。

Provider Factors Likely to Impact Access and Uptake of Long-Acting Injectable Cabotegravir for Transgender Women in the United States: Results of a Qualitative Study.

机构信息

Christine Tagliaferri Rael, PhD, is an Assistant Professor in the University of Colorado College of Nursing, Aurora, Colorado, USA. Doyel Das, BS, is an MPH Student in the Columbia University Mailman School of Public Health, New York, New York, USA. Jonathan Porter, MPH, was an MPH Student in the Columbia University Mailman School of Public Health, New York, New York, USA, and a Professional Research Assistant in the University of Colorado College of Nursing, Aurora, Colorado, USA. He is currently a Research Consultant, Optem Serve Consulting/The Lewin Group, New York, New York, USA. Javier Lopez-Ríos, PhD, MPH is an Assistant Professor in the Dornsife School of Public Health at Drexel University, Philadelphia, Philadelphia, USA. Elena Abascal, DNP, NP, was a DNP student at the Columbia University School of Nursing, New York, New York, USA, and a Clinical Research Nurse at the New York State Psychiatric Institute (NYSPI), New York, New York, USA. She is currently a Nurse Practitioner, Columbia University Irving Medical Center/New York Presbyterian Morgan Stanley Children's Hospital, New York, New York, USA. Curtis Dolezal, PhD is an Assistant Clinical Professor in the HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute/Columbia University Psychiatry, New York, New York, USA. Michael P. Vaughn, PhD, MPH was a Postdoctoral Research Fellow in the HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute/Columbia University Psychiatry, New York, New York, USA. He is currently the Research Operations Lead (Experience Design), Capital One Bank, New York, New York, USA. Pilar Giffenig, DNP, MSN, APRN, FNP-C, was a DNP student at the Columbia University School of Nursing, New York, New York, USA, and a Clinical Research Nurse at the New York State Psychiatric Institute, New York, New York, USA. She is currently a Nurse Practitioner, RemoteFocus, New York, New York, USA. Jasmine M. Lopez, BS, is a Research Assistant in the HIV Center for Clinical and Behavioral Studies at NYSPI/Columbia University Psychiatry, New York, New York, USA. Samantha Stonbraker, PhD, MPH, RN, is an Assistant Professor in the University of Colorado College of Nursing, Aurora, Colorado, USA. Christina Sun, PhD, is an Associate Professor in the University of Colorado Collee of Nursing, Aurora, Colorado, USA. Roque Anthony Velasco, MS, NP, is a PhD Student in the University of Colorado College of Nursing, Aurora, Colorado, USA. Leandra Bitterfeld, RN, is a PhD Student in the University of Colorado College of Nursing, Aurora, CO, USA. Walter O. Bockting, PhD, is a Professor and Co-Chief of the Gender Health and Sexuality Area at New York State Psychiatric Institute/Columbia University, New York, New York, USA, and a Professor in the Columbia University School of Nursing, New York, New York, USA. Jose Bauermeister, PhD, MPH, FSBM, is a Professor in the School of Nursing and School of Medicine and the Albert M Greenfield University Professor of Human Relations at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

出版信息

J Assoc Nurses AIDS Care. 2024;35(5):437-449. doi: 10.1097/JNC.0000000000000488. Epub 2024 Aug 13.

DOI:10.1097/JNC.0000000000000488
PMID:39137316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11361836/
Abstract

Long-acting injectable cabotegravir (CAB-LA) was US Food and Drug Administration-approved in 2021. However, little is known about providers' CAB-LA knowledge, attitudes, challenges, and prescribing preferences for transgender women patients. Understanding this is critical to developing new pre-exposure prophylaxis (PrEP) interventions tailored to transgender women. We conducted 45-min, in-depth Zoom interviews (IDIs) with United States-based health care providers who prescribe PrEP to transgender women. IDIs focused on providers' CAB-LA knowledge/acceptability, willingness to prescribe CAB-LA to transgender women, potential challenges, and solutions to mitigate challenges. Providers ( N = 17) had a mean age of 43 years, and 35.4% ( n = 6) identified as people of color. Most ( n = 12) had basic knowledge of CAB-LA but wanted additional training. All participants found CAB-LA acceptable and were willing to prescribe. Most ( n = 11) anticipated minimal challenges to implementation. Others ( n = 4) reported potential issues, including logistical/scheduling concerns that impede CAB-LA integration and staffing concerns. Many providers expressed support for self-injection ( n = 13) and injections at "drop-in" clinics ( n = 8) to overcome challenges.

摘要

长效注射型卡替拉韦(CAB-LA)于 2021 年获得美国食品和药物管理局批准。然而,对于医疗服务提供者在为跨性别女性患者开处方时,对 CAB-LA 的了解、态度、挑战和偏好知之甚少。了解这些问题对于开发新的针对跨性别女性的暴露前预防(PrEP)干预措施至关重要。我们对在美国为跨性别女性开 PrEP 处方的医疗服务提供者进行了 45 分钟的深入 Zoom 访谈(IDIs)。IDIs 主要关注提供者对 CAB-LA 的了解/可接受性、为跨性别女性开 CAB-LA 的意愿、潜在挑战以及缓解挑战的解决方案。提供者(N=17)的平均年龄为 43 岁,35.4%(n=6)为有色人种。大多数(n=12)对 CAB-LA 有基本了解,但希望接受额外培训。所有参与者都认为 CAB-LA 是可以接受的,并愿意开处方。大多数(n=11)预计实施过程中几乎没有挑战。其他人(n=4)报告了潜在问题,包括影响 CAB-LA 整合的后勤/调度问题和人员配备问题。许多提供者表示支持自我注射(n=13)和在“随到随诊”诊所进行注射(n=8),以克服挑战。