Wuxi School of Medicine, Jiangnan University, Wuxi 214028, China; Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Biomed Pharmacother. 2024 Sep;178:117194. doi: 10.1016/j.biopha.2024.117194. Epub 2024 Aug 12.
Gastric cancer is a remarkably heterogeneous tumor. Despite some advances in the diagnosis and treatment of gastric cancer in recent years, the precise treatment and curative outcomes remain unsatisfactory. Poor prognosis continues to pose a major challenge in gastric cancer. Therefore, it is imperative to identify effective targets to improve the treatment and prognosis of gastric cancer patients. It should be noted that glycosylation, a novel form of posttranslational modification, is a process capable of regulating protein function and influencing cellular activities. Currently, numerous studies have shown that glycosylation plays vital roles in the occurrence and progression of gastric cancer. As crucial enzymes that regulate glycan synthesis in glycosylation processes, glycosyltransferases are potential targets for treating GC. Hence, investigating the regulation of glycosyltransferases and the expression of associated proteins in gastric cancer cells is highly important. In this review, the related glycosyltransferases and their related signaling pathways in gastric cancer, as well as the existing inhibitors of glycosyltransferases, provide more possibilities for targeted therapies for gastric cancer.
胃癌是一种具有显著异质性的肿瘤。尽管近年来在胃癌的诊断和治疗方面取得了一些进展，但精确的治疗和疗效仍不尽如人意。不良预后仍然是胃癌面临的主要挑战。因此，有必要确定有效的靶点，以改善胃癌患者的治疗和预后。值得注意的是，糖基化是一种新型的翻译后修饰形式，是一种能够调节蛋白质功能并影响细胞活动的过程。目前，大量研究表明糖基化在胃癌的发生和发展中起着至关重要的作用。作为糖基化过程中调节聚糖合成的关键酶，糖基转移酶是治疗 GC 的潜在靶点。因此，研究糖基转移酶在胃癌细胞中的调节作用及其相关蛋白的表达具有重要意义。在这篇综述中，讨论了与胃癌相关的糖基转移酶及其相关信号通路，以及现有的糖基转移酶抑制剂，为胃癌的靶向治疗提供了更多的可能性。
