Drnovsek Eva, Parichenko Alexandra, Power Guerra Nicole, Pabst Julia, Wunderlich Kristof, Falkenburger Björn, Huang Shirong, Cuniberti Gianaurelio, Haehner Antje, Hummel Thomas
Smell & Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Institute for Materials Science and Max Bergmann Center for Biomaterials, Technische Universität Dresden, Dresden, Germany.
Parkinsonism Relat Disord. 2024 Oct;127:107091. doi: 10.1016/j.parkreldis.2024.107091. Epub 2024 Aug 6.
Patients with Parkinson's Disease (PD) have a distinctive body odor, which was first described by a patient's wife as musky and strong. Later analysis of sebum of patients with PD revealed four volatile organic compounds (VOC) (perillic aldehyde, hippuric acid, eicosane, octadecanal), that differed from healthy subjects, and the patient's wife confirmed that three of them smelled like patients with PD. However, it is unclear whether other people can also perceive this PD body odor and whether it can be artificially recreated. Hence, we aimed to systematically assess whether young women can perceive the PD body odor and whether they can discriminate between the PD body odor and the "artificial PD odor" composed of the four VOCs mentioned above.
T-shirts were collected from 19 people with idiopathic PD and 15 age- and gender-matched healthy participants to represent the PD body odor and the healthy body odor, respectively. The four VOCs were diluted in 1,2-propanediol to prepare the artificial PD body odor. Body odors were rated by 26 young women.
PD body odor was perceived as more musty, strong, smelly, and unpleasant compared to healthy and artificial PD body odor. Furthermore, around 80 % of women were able to discriminate PD body odor from artificial PD body odor.
Overall, this study confirmed a distinctive body odor quality of patients with PD, which can be perceived by young women. However, the four VOCs, composing the artificial PD body odor, were insufficient to reproduce the body odor from PD patients.
帕金森病（PD）患者有一种独特的体味，最早由一位患者的妻子描述为麝香味且浓烈。后来对PD患者皮脂的分析揭示了四种挥发性有机化合物（VOC）（紫苏醛、马尿酸、二十烷、十八醛），这些与健康受试者不同，且该患者的妻子证实其中三种闻起来像PD患者。然而，尚不清楚其他人是否也能察觉到这种PD体味，以及它是否可以人工再现。因此，我们旨在系统评估年轻女性是否能察觉到PD体味，以及她们是否能区分PD体味和由上述四种VOC组成的“人工PD气味”。
从19名特发性PD患者和15名年龄及性别匹配的健康参与者那里收集T恤，分别代表PD体味和健康体味。将四种VOC在1,2 - 丙二醇中稀释以制备人工PD体味。由26名年轻女性对体味进行评分。
与健康体味和人工PD体味相比，PD体味被认为更有霉味、浓烈、难闻且令人不适。此外，约80%的女性能够区分PD体味和人工PD体味。
总体而言，本研究证实了PD患者有一种独特的体味特征，年轻女性能够察觉到。然而，构成人工PD体味的四种VOC不足以重现PD患者的体味。
