Centre régional en Antibiothérapie Normandie, CRAtb « NormAntibio », Centre Hospitalo-Universitaire, Caen, Normandie, France; Normandie Univ, UNICAEN, UNIROUEN, Inserm UMR 1311 DYNAMICURE, 14000 Caen, France.
Centre régional en Antibiothérapie Normandie, CRAtb « NormAntibio », Centre Hospitalo-Universitaire, Caen, Normandie, France; Normandie Univ, UNICAEN, UNIROUEN, Inserm UMR 1311 DYNAMICURE, 14000 Caen, France.
Infect Dis Now. 2024 Oct;54(7):104962. doi: 10.1016/j.idnow.2024.104962. Epub 2024 Aug 11.
In France, 75% of systemic antibiotics are prescribed by general practitioners (GPs) in primary care. We aimed to estimate the burden of inappropriate use related to excessive prescription duration.
In 2021, we performed a cross-sectional and pharmaco-economic study of a network of six GPs. The references for optimal durations were those of the French national guidelines for antibiotic prescription.
Out of 196 antibiotic prescriptions, 33.7 % were of excessive duration, with a mean excess of 0.9 [0.86-0.94] to 1.6 [1.45-1.72] days per prescription. Ear, nose, and throat, respiratory tract, and skin and skin structure infections were the main infections associated with excessive prescription. The pharmaco-economic analysis showed that the cost of excessive prescription duration would range from an estimated 151 to 262 million € in France in 2021.
Addressing excessive antibiotic prescription duration by GPs may represent a powerful and cost-saving tool in antimicrobial stewardship programs.
在法国，75%的全身用抗生素由初级保健中的全科医生（GP）开具。我们旨在评估与处方持续时间过长相关的不适当使用的负担。
2021 年，我们对六个 GP 的网络进行了一项横断面和药物经济学研究。最佳持续时间的参考标准是法国国家抗生素处方指南。
196 份抗生素处方中，33.7%的处方持续时间过长，平均每处方多 0.9[0.86-0.94]至 1.6[1.45-1.72]天。耳、鼻、喉、呼吸道和皮肤及皮肤结构感染是与处方过长相关的主要感染。药物经济学分析表明，2021 年法国因处方持续时间过长而导致的费用估计在 1.51 亿至 2.62 亿欧元之间。
解决 GP 中抗生素处方持续时间过长的问题可能是抗菌药物管理计划中一个强大且具有成本效益的工具。
