Thomas Justin, Tandon Ruchika, Mani Vinita Elizabeth
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Int J Neurosci. 2024 Aug 19:1-3. doi: 10.1080/00207454.2024.2392120.
Here we report a child of Gullian Barre syndrome (GBS) with opisthotonic posturing and we subsequently detected Scrub typhus in him.
An 11-year-old boy presented with progressive motor quadriparesis with transient bladder retention, bilateral facial weakness, diminished gag reflex, absent reflexes and his nerve conduction studies suggested Acute Motor Axonal Neuropathy (AMAN) GBS. His power gradually started recovering after one week. However, he had opisthotonus and signs of meningeal irritation. The child's CSF examination was consistent with GBS. His bacterial, fungal, tubercular microscopy and cultures and viral markers were negative. IgM for Borrelia and Leptospira and HIV ELISA were negative. IgM for scrub typhus, however, came out to be positive. Hence, we gave him azithromycin and he recovered almost completely in 3 months.
To our knowledge there is no previous report of opisthotonic posturing in GBS patients. This could be due to radicular involvement in immune mediated etiology of GBS.
在此我们报告一例患有颈后弓反张姿势的吉兰-巴雷综合征(GBS)患儿,随后我们在其体内检测到恙虫病。
一名11岁男孩出现进行性四肢瘫,伴有短暂性膀胱潴留、双侧面部无力、咽反射减弱、反射消失,其神经传导研究提示急性运动轴索性神经病(AMAN)型GBS。一周后他的肌力逐渐开始恢复。然而,他出现了颈后弓反张及脑膜刺激征。该患儿的脑脊液检查结果与GBS相符。其细菌、真菌、结核杆菌显微镜检查及培养以及病毒标志物均为阴性。伯氏疏螺旋体和钩端螺旋体IgM以及HIV酶联免疫吸附测定均为阴性。然而,恙虫病IgM呈阳性。因此,我们给予他阿奇霉素治疗,3个月后他几乎完全康复。
据我们所知,此前尚无GBS患者出现颈后弓反张姿势的报告。这可能是由于GBS免疫介导病因中的神经根受累所致。