Gray Penelope, Mariz Filipe Colaço, Eklund Carina, Eriksson Tiina, Faust Helena, Kann Hanna, Müller Martin, Paavonen Jorma, Pimenoff Ville N, Sehr Peter, Surcel Heljä-Marja, Dillner Joakim, Waterboer Tim, Lehtinen Matti
Center for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Tumorvirus-Specific Vaccination Strategies, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 242, 69120, Heidelberg, Germany.
NPJ Vaccines. 2024 Aug 13;9(1):146. doi: 10.1038/s41541-024-00941-w.
Although HPV vaccines are highly efficacious, a notable proportion of quadrivalent vaccinees are HPV18 seronegative post-vaccination. We have investigated this findings' validity by comparing vaccine-induced antibody responses using two different immunoassays. 6558 16-17-year-old females participated in the FUTURE II (NCT00092534) and PATRICIA (NCT00122681) trials in 2002-2004. Both the quadrivalent and bivalent vaccine recipients (QVR and BVR) received three doses. Twelve-year follow-up for 648 vaccinees was conducted by the Finnish Maternity Cohort. The presence of neutralising and binding HPV antibodies was analysed via HPV pseudovirion-based neutralisation and pseudovirion-binding assays. Four percent and 14.3% of the QVRs were seronegative for neutralising and binding antibodies to HPV16 and HPV18, respectively. No BVRs were HPV16/18 seronegative post-vaccination. The antibody titres were strongly correlated between the assays, Pearson's correlation coefficient, r = 0.92 and 0.85, and r = 0.91 and 0.86 among the QVRs and BVRs respectively. Fourteen percent of QVRs lacked detectable HPV18 antibodies in long-term follow-up.
尽管人乳头瘤病毒（HPV）疫苗具有很高的效力，但相当一部分接种四价疫苗的人在接种后对HPV18呈血清阴性。我们通过使用两种不同的免疫测定法比较疫苗诱导的抗体反应，来研究这一结果的有效性。2002年至2004年，6558名16 - 17岁的女性参与了FUTURE II（NCT00092534）和PATRICIA（NCT00122681）试验。四价疫苗和二价疫苗的接种者（QVR和BVR）均接种了三剂。芬兰孕产妇队列对648名接种者进行了12年的随访。通过基于HPV假病毒的中和试验和假病毒结合试验分析了中和性和结合性HPV抗体的存在情况。QVR中分别有4%和14.3%的人对HPV16和HPV18的中和抗体和结合抗体呈血清阴性。接种疫苗后，没有BVR对HPV16/18呈血清阴性。两种测定法之间的抗体滴度高度相关，QVR和BVR中的Pearson相关系数分别为r = 0.92和0.85，以及r = 0.91和0.86。在长期随访中，14%的QVR检测不到HPV18抗体。
