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Kinetics of dark repair inhibition in ultraviolet damaged DNA by substituted quinolines.

作者信息

Sideropoulos A S, Betz M K

出版信息

Microbios. 1985;44(177):45-9.

PMID:3913843
Abstract

The effects of chloroquine on the kinetics of the dark repair process were investigated by employing a cellular system. Lineweaver-Burke plots and Dixon plots of chloroquine inhibition, respectively, showed that there was an increase in slope with increasing concentration of inhibitor which followed an enzyme-like pattern. These results are consistent with a model for excision-repair in which chloroquine may block the excision repair pathway.

摘要

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