利用 3D 结构域交换构建配体结合控制的血红素蛋白组装体。
Construction of ligand-binding controlled hemoprotein assemblies utilizing 3D domain swapping.
机构信息
Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Medilux Research Center, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
出版信息
Chem Commun (Camb). 2024 Aug 27;60(70):9440-9443. doi: 10.1039/d4cc03129f.
Association-controllable hemoprotein assemblies were constructed from a fusion protein containing two c-type cytochrome units using 3D domain swapping. The hemoprotein assembly exhibited a dynamic exchange between cyclic and linear structures and could be regulated by carbon monoxide (CO) and imidazole binding.
采用三维结构域交换，从包含两个 c 型细胞色素单元的融合蛋白构建了具有关联控制能力的血红素蛋白组装体。该血红素蛋白组装体表现出环状和线性结构之间的动态交换，并可通过一氧化碳 (CO) 和咪唑结合进行调节。
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