Liang Hai, Wu Fan, Xia Runan, Wu Wei, Li Shiqi, Di Panpan, Yang Miao
Department of Pharmacy, The People's Hospital of Bozhou Bozhou Anhui Province China
School of Physics and Optoelectronic Engineering, Anhui University Hefei 230601 Anhui P. R. China.
RSC Adv. 2024 Aug 12;14(35):25301-25306. doi: 10.1039/d4ra02987a.
Silicon quantum dots (SiQDs) and carbon quantum dots (CQDs) are renowned for their outstanding applications in fluorescence imaging and biosensing. However, their small size poses significant challenges in terms of preparation, collection, and purification. Polyhedral oligomeric silsesquioxanes (POSS), an organic-inorganic nanohybrid with a cage-like structure, has recently attracted considerable attention due to its excellent biocompatibility. In this research, we utilize the encapsulating properties of POSS to improve the optical property of SiQDs/CQDs through an synthesis strategy, resulting in the production of blue-emitting POSS-SiQDs, green-emitting POSS-G-CNDs, and red-emitting POSS-R-CNDs. By examining their structural and optical characteristics, it is found that these hybrid materials exhibit excellent luminescent properties, biocompatibility and cell membrane permeability. This facilitates multicolor intracellular imaging and underscores their successful application in biological imaging. Our study presents a novel approach to synthesize POSS-QDs composite nanomaterials with new perspectives in biological imaging and medical diagnostics.
硅量子点（SiQDs）和碳量子点（CQDs）因其在荧光成像和生物传感方面的出色应用而闻名。然而，它们的小尺寸在制备、收集和纯化方面带来了重大挑战。多面体低聚倍半硅氧烷（POSS）是一种具有笼状结构的有机-无机纳米杂化物，由于其优异的生物相容性，最近受到了相当大的关注。在本研究中，我们利用POSS的封装特性，通过一种合成策略来改善SiQDs/CQDs的光学性能，从而制备出发蓝光的POSS-SiQDs、发绿光的POSS-G-CNDs和发红光的POSS-R-CNDs。通过研究它们的结构和光学特性，发现这些杂化材料具有优异的发光性能、生物相容性和细胞膜通透性。这有利于进行多色细胞内成像，并突出了它们在生物成像中的成功应用。我们的研究提出了一种合成POSS-QDs复合纳米材料的新方法，为生物成像和医学诊断提供了新的视角。
